Effects of Interval Training Effects on Cardiac Fibrosis

NCT04038723 | Completed

• 1 other identifier: 103-7333A3
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study aimed to highlight the effect of high-intensity interval training (HIIT) on cardiac fibrosis in cardiac patients. From 2009-2018, cardiac patients with measurements of VO2peak, b-type natriuretic peptide, quality of life questionnaire, cardiovascular magnetic resonance imaging with late gadolinium enhancement (CMR-LGE), and preserved serum before and after 36 times of HIIT were enrolled. The human cardiac fibroblast (CF) isolated from human adult ventricle is treated with sera before and after HIIT. Measurements of cell migration as well as cell proliferation and global cell protein profiles before and after HIIT will be performed.

Conditions

Fibrosis Myocardial

Keywords

Fibrosis; Ventricle Remodeling; Exercise Training; Proteomics

Outcome Measures

Primary Outcomes (6)

• Cardiac output (CO)

  Cardiac output in milliliter per minute measured by cardiac magnetic resonance imaging with late gadolinium enhancement before and after exercise training

  3-4 months (for 36 times of exercise training)

• Cardiac mass

  Cardiac mass in gram measured by cardiac magnetic resonance imaging with late gadolinium enhancement before and after exercise training

  3-4 months (for 36 times of exercise training)

• Left ventricular end-systolic volume (LVESV)

  LVESV in milliliter measured by cardiac magnetic resonance imaging with late gadolinium enhancement before and after exercise training

  3-4 months (for 36 times of exercise training)

• Left ventricular end-diastolic volume (LVEDV)

  LVEDV in milliliter measured by cardiac magnetic resonance imaging with late gadolinium enhancement before and after exercise training

  3-4 months (for 36 times of exercise training)

• Extracellular volume fraction (ECV)

  ECV in percent (%) measured by cardiac magnetic resonance imaging with late gadolinium enhancement before and after exercise training

  3-4 months (for 36 times of exercise training)

• Proteomics

  Protein level changes in fold change in cardiac fibroblast before and after exercise training

  3-4 months (for 36 times of exercise training)

Secondary Outcomes (12)

• Peak exercise capacity (VO2peak)

  3-4 months (for 36 times of exercise training)

• Peak cardiac output (CO)

  3-4 months (for 36 times of exercise training)

• Oxygen uptake efficiency slope (OUES)

  3-4 months (for 36 times of exercise training)

• Ventilation/VCO2 ratio (Ve-VCO2)

  3-4 months (for 36 times of exercise training)

• Migration speed

  3-4 months (for 36 times of exercise training)

Study Arms (1)

Pre- and Post-HIIT

EXPERIMENTAL

Participants will be evaluated before and after exercise training.

Behavioral: High-intensity interval training

Interventions

High-intensity interval training BEHAVIORAL

Cardiac patients have completed 36 times of exercise training with the exercise frequency of 2-3 times per week. Subjects performed five 3-minute intervals at 80% of VO2peak and each interval was separated by 3-minute exercise at 40% of VO2peak after the warm-up period. The exercise session was terminated by 3-minute cool-down at 30% of VO2peak.

Pre- and Post-HIIT

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Heart failure patients, diagnosed according to the Framingham heart failure diagnostic criteria, with stable clinical status for greater than 4 weeks after conservative treatment or intervention were enrolled in the study.

You may not qualify if:

• Those who were
• \< 20 years
• under anti-coagulant therapy
• unable to exercise \> 1 year owing to non-cardiovascular disease
• pregnant or plan to be pregnant within one year
• plan to have cardiac transplant within 6 months
• uncorrected valvular heart disease related heart failure
• congenital heart disease related heart failure
• Other exercise contraindications：
• unstable angina
• resting systolic blood pressure\> 200 mmHg or resting diastolic blood pressure\> 110 mmHg
• orthostatic blood pressure drop (systolic blood pressure drop \> 20 mmHg)。
• critical aortic stenosis stenosis (peak systolic pressure gradient\> 50 mmHg and aortic valve opening \< 0.75 cm2)。
• acute fever
• uncontrolled uncontrolled atrial or ventricular dysrhythmias

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Related Publications (1)

• Hsu CC, Wang JS, Shyu YC, Fu TC, Juan YH, Yuan SS, Wang CH, Yeh CH, Liao PC, Wu HY, Hsu PH. Hypermethylation of ACADVL is involved in the high-intensity interval training-associated reduction of cardiac fibrosis in heart failure patients. J Transl Med. 2023 Mar 10;21(1):187. doi: 10.1186/s12967-023-04032-7.

  PMID: 36894992 DERIVED

MeSH Terms

Conditions

Fibrosis; Ventricular Remodeling

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pathological Conditions, Anatomical

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 18, 2019
• First Posted: July 31, 2019
• Study Start: August 1, 2015
• Primary Completion: July 31, 2018
• Study Completion: July 31, 2018
• Last Updated: July 31, 2019

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share