Trials Sponsors Conditions Drugs Pricing

Conditions

ARDS on Invasive Mechanical Ventilation Respiratory Failure

Keywords

Limited driving pressureLow tidal volumeLung injury score

Outcome Measures

Primary Outcomes (1)

Lung injury score
Lung injury score (LIS, Murray score)
Day 7 after invasive mechanical ventilation

Secondary Outcomes (2)

28 days Mortality
Upto 28 days
New onset of ARDS
Upto 28 days

Study Arms (2)

Limited driving pressure ventilation

EXPERIMENTAL

Procedure: Limited driving pressure

Conventional mechanical ventilation strategies

EXPERIMENTAL

Procedure: Conventional mechanical ventilation strategies

Interventions

Limited driving pressureProcedure

Keep driving pressure \<15 cmH2O

Limited driving pressure ventilation

Conventional mechanical ventilation strategiesProcedure

Keep tidalvolume \</= 8

Conventional mechanical ventilation strategies

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Age ≥ 18 year old MICU patient
On Invasive mechanical ventilator less than 24 hr. before randomization

You may not qualify if:

Sponsors & Collaborators

Mahidol University
Otherlead

Study Sites (1)

Mahidol university

Bangkok Noi, Bangkok, 10700, Thailand

Related Publications (1)

Tongyoo S, Viarasilpa T, Deawtrakulchai P, Subpinyo S, Suppasilp C, Permpikul C. Comparison of limited driving pressure ventilation and low tidal volume strategies in adults with acute respiratory failure on mechanical ventilation: a randomized controlled trial. Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241249152. doi: 10.1177/17534666241249152.
PMID: 38726850DERIVED

MeSH Terms

Conditions

Respiratory Insufficiency

Condition Hierarchy (Ancestors)

Respiration DisordersRespiratory Tract Diseases

Study Officials

Surat Tongyoo, MD
Mahidol University
PRINCIPAL INVESTIGATOR

Enrollment

126 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

July 25, 2019

First Posted

July 29, 2019

Study Start

July 25, 2019

Actual (reported)

Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (2)

Limited driving pressure ventilation

Conventional mechanical ventilation strategies

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (2)

Limited driving pressure ventilation

Conventional mechanical ventilation strategies

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations