Effects of Anesthetic Techniques on Renal Function
Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children
1 other identifier
observational
60
1 country
1
Brief Summary
This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2019
CompletedFirst Submitted
Initial submission to the registry
July 2, 2019
CompletedFirst Posted
Study publicly available on registry
July 24, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2019
CompletedOctober 21, 2019
October 1, 2019
9 months
July 2, 2019
October 17, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
renal blood flow
Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)
2 days
Secondary Outcomes (4)
neutrophil gelatinase-associated lipocalin , NGAL
2 days
creatinine
3 and 4 days
Mean arterial pressure
2 days
cardiopulmonary bypass (CPB) time
24 hours
Study Arms (2)
Group A: Sevoflurane, sufentanil and rocuronium
sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required
Group B: Propofol, sufentanil and rocuronium
propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required
Interventions
sevoflurane was used to maintain anesthesia
propofol was used to maintain anesthesia
Eligibility Criteria
After approved by the ethics committee, sixty patients who met the inclusion criteria of this study with their parents' informed consent in Children's Hospital of Fudan University.
You may qualify if:
- children with congenital heart disease
- \<3 years of age
You may not qualify if:
- preoperative renal insufficiency;
- renal malformation, kidney absence
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Huiying Shaolead
Study Sites (1)
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
mazhong zhang, MD
Shanghai Children's Medical Center
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- The attending anesthesiologist
Study Record Dates
First Submitted
July 2, 2019
First Posted
July 24, 2019
Study Start
January 1, 2019
Primary Completion
September 30, 2019
Study Completion
September 30, 2019
Last Updated
October 21, 2019
Record last verified: 2019-10