Tool for Inappropriate Prescription Evaluation: The TaIPE Study
TaIPE
1 other identifier
interventional
464
1 country
1
Brief Summary
A mono-center, randomized controlled trial will be conducted at the University Hospital of Lausanne. Hospitalized patients will be randomly assigned from the emergency department to two sub-units composing the acute care for elders (ACE) unit. In one subunit, potentially inappropriate prescriptions will be detected and treatment optimized according PIM-Check. In the other, STOPP/START criteria will be independently applied.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 26, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2019
CompletedFirst Submitted
Initial submission to the registry
July 17, 2019
CompletedFirst Posted
Study publicly available on registry
July 22, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
August 4, 2019
CompletedJuly 23, 2019
July 1, 2019
1.2 years
July 17, 2019
July 22, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Rate of Potentially Inappropriate Prescriptions (PIPs) reduction in the PIM-Check group compared to STOPP/START
18 months
Secondary Outcomes (10)
Number and type of PIPs detected by each tool
18 months
Rate of acceptability
18 months
Number of treatment (mean and median) modification by clinicians
18 months
Number of drugs at discharge
18 months
Incidence rate of falls
18 months
- +5 more secondary outcomes
Study Arms (2)
PIM-Check group
EXPERIMENTALSTOPP/START group
ACTIVE COMPARATORInterventions
In the PIM-Check group, a medication review will be conducted using PIM-Check within 72 hours of patient's admittance to the unit. The physician will decide whether to accept these recommendations or not and implement prescribing changes if agreed.
In the STOPP/START group, medication lists will be analyzed within 72 hours of patient's admittance and optimized according to STOPP/START criteria. The second physician will decide whether to accept these recommendations or not and implement prescribing changes if agreed.
Eligibility Criteria
You may qualify if:
- All patients meeting the admission criteria of the acute care for elders (ACE) unit will be eligible.
You may not qualify if:
- none
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, 1011, Switzerland
Related Publications (1)
Farhat A, Al-Hajje A, Lang PO, Csajka C. Impact of Pharmaceutical Interventions with STOPP/START and PIM-Check in Older Hospitalized Patients: A Randomized Controlled Trial. Drugs Aging. 2022 Nov;39(11):899-910. doi: 10.1007/s40266-022-00974-7. Epub 2022 Sep 30.
PMID: 36175740DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 17, 2019
First Posted
July 22, 2019
Study Start
February 26, 2018
Primary Completion
April 30, 2019
Study Completion
August 4, 2019
Last Updated
July 23, 2019
Record last verified: 2019-07