The Role of Netrin -1 in Acute Coronary Syndrome

NCT04027127 | Completed

• 1 other identifier: aksaray 2013-23
• Study Type: interventional
• Target: 238
• Locations: 0 countries
• Sites: N/A

Brief Summary

In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher Netrin-1 levels.

Conditions

Acute Coronary Syndrome

Keywords

netrin-1; acs; reperfuzion

Outcome Measures

Primary Outcomes (1)

• serum netrin-1 value

  Netrin-1 in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Mybıosource MBS044526 ) All assays were performed in duplicate. Plasma Netrin-1 is expressed in picograms (pg) per mg.

  30 minute

Study Arms (2)

ACS GRUP

ACTIVE COMPARATOR

Demographic characteristics, history, vital signs, laboratory findings, coronary angiography (CAG) and echocardiography (ECO) findings of the patients were recorded. Netrin-1 levels were studied with blood collected at the hospital and 6-8 hours after CAG. CAG results were evaluated by TIMI flow. The patients were divided into two groups with and without TIMI 3 flow and Netrin-1 levels were compared. GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Ischemia) clinical risk assessments were performed and Netrin-1 values were compared.

Other: netrin-1 value on admission to hospital

plasebo grup

ACTIVE COMPARATOR

It consisted of those without any disease and netri-1 values at admission were compared with the uptake patient group.

Other: netrin-1 value on admission to hospital

Interventions

netrin-1 value on admission to hospital OTHER

ACS GRUP; plasebo grup

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients over the age of 18
• diagnose ACS
• patients undergoing angiography

You may not qualify if:

• CVE history
• Neurological disease
• Pregnancy and Lactation
• Liver failure
• Diagnosed malignity
• Use of anticonvulsant and nephrotoxic medication
• Chronic kidney disease
• Not having angiography
• Developing acute renal failure after angiography
• Patients who rejected to participate were excluded.

Sponsors & Collaborators

• Aksaray University Training and Research Hospital: lead

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Officials

• Hüseyin Mutlu, MD

  Aksaray/Turkey

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Patient group; Those diagnosed with ACS over 18 years of age, planned angiography and accepted angiography. The control group consisted of volunteers without disease.
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst. Prof. Dr. Principal Investigator

Model Details: PATIENT AND CONTROL GROUP will be divided into two.

Study Record Dates

• First Submitted: June 18, 2019
• First Posted: July 19, 2019
• Study Start: September 15, 2013
• Primary Completion: August 15, 2014
• Study Completion: June 15, 2018
• Last Updated: July 19, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share