Effect of Proton Pump Inhibitor of Daily Use for One Month on Kidney Function Test

NCT04022837 | Unknown Phase 2

• 1 other identifier: PPIs on kidney
• Study Type: interventional
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study to: evaluate the association between prolonged use of PPI and adverse renal outcomes on patients with normal renal function and others with abnormal renal function

Conditions

Proton Pump Inhibitor Allergy

Outcome Measures

Primary Outcomes (1)

• kidney function

  eGFR=175xage(y/0)x\^(-0.203)xplasma creatinine (mg/dl)x\^(-1.154)

  one month

Study Arms (2)

pantoprazole with normal kidney function

EXPERIMENTAL

use pantoprazole for one month and after one month i will do for them kidney functions test

Drug: Pantoprazole 40mg

pantoprazole with abnormal kidney function

EXPERIMENTAL

use pantoprazole for one month and after one month i will do for them kidney functions test

Drug: Pantoprazole 40mg

Interventions

Pantoprazole 40mg DRUG

effect of this drug on renal function

Also known as: Protonix

pantoprazole with abnormal kidney function; pantoprazole with normal kidney function

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients with peptic ulcer disease or gastroesophagial reflux with normal l renal function
• patients with peptic ulcer disease or gastroeosophagial reflux with abnormal renal function

You may not qualify if:

• cigarette smoker: Cigarette smoking status was defined categorically as current,former, or never smoker at baseline.
• biabetic patients: diabetes mellitus is defined by a fasting blood glucose concentration \>\_ 126 mg/dl ,random glucose level of \>200 mg 3-patients take corticosteroid 4-patients with hypersensitivity to these drugs

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Interventions

Pantoprazole

Intervention Hierarchy (Ancestors)

2-Pyridinylmethylsulfinylbenzimidazoles; Sulfoxides; Sulfur Compounds; Organic Chemicals; Pyridines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Benzimidazoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: July 3, 2019
• First Posted: July 17, 2019
• Study Start: November 1, 2019
• Primary Completion: November 1, 2020
• Study Completion: December 1, 2021
• Last Updated: July 17, 2019

Record last verified: 2019-07