Effect of Daily Use Proton Pump Inhibitors for One Month on Kidney Function
the Effect of Daily Use of Proton Pump Inhibitors for One Month on Renal Function
1 other identifier
interventional
200
0 countries
N/A
Brief Summary
The aim of this study to: evaluate the association between prolonged use of PPI and adverse renal outcomes on patients with normal renal function and others with abnormal renal function
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Dec 2019
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 3, 2019
CompletedFirst Posted
Study publicly available on registry
April 10, 2019
CompletedStudy Start
First participant enrolled
December 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2021
CompletedJuly 17, 2019
July 1, 2019
1 year
April 3, 2019
July 15, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
kidney function
eGFR=175xage(y/0)x\^(-0.203)xplasma creatinine (mg/dl)x\^(-1.154)
one month
Study Arms (2)
pantoprazole with normal kidney function
EXPERIMENTALuse pantoprazole for one month and after one month i will do for them kidney functions test
pantoprazole with abnormal kidney function
EXPERIMENTALuse pantoprazole for one month and after one month i will do for them kidney functions test
Interventions
effect of this drug on renal function
Eligibility Criteria
You may qualify if:
- patients with peptic ulcer disease or gastroesophagial reflux with normal l renal function
- patients with peptic ulcer disease or gastroeosophagial reflux with abnormal renal function
You may not qualify if:
- cigarette smoker: Cigarette smoking status was defined categorically as current,former, or never smoker at baseline.
- biabetic patients: diabetes mellitus is defined by a fasting blood glucose concentration \>\_ 126 mg/dl ,random glucose level of \>200 mg/dl.
- patients take corticosteroid 4-patients with hypersensitivity to these drugs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Desbuissons G, Deray G, Mercadal L. [Proton pump inhibitors and kidney]. Nephrol Ther. 2018 Apr;14 Suppl 1:S115-S124. doi: 10.1016/j.nephro.2017.06.005. Epub 2017 Dec 20. French.
PMID: 29274872BACKGROUNDMak SK, Loo CK, Wong PN, Lo KY, Tong GM, Lam EK, Wong AK. A retrospective study on efficacy of proton-pump inhibitor-based triple therapy for eradication of Helicobacter pylori in patients with chronic renal failure. Singapore Med J. 2003 Feb;44(2):74-8.
PMID: 14503780BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
samir k abdel-hameed
Assiut University
- STUDY DIRECTOR
mohammad y kobeisy, prof
Assiut University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- director .samir kamal abdel-hameed
Study Record Dates
First Submitted
April 3, 2019
First Posted
April 10, 2019
Study Start
December 1, 2019
Primary Completion
December 1, 2020
Study Completion
October 1, 2021
Last Updated
July 17, 2019
Record last verified: 2019-07