NCT04020731

Brief Summary

Use of hypnosis for therapeutic purposes tends to spread. However, the neural mechanisms underlying hypnosis is still debated and no specific change has yet been associated with this state. In this context, it seems necessary to clarify its mechanisms and effects. Since hypnosis induces a change of consciousness state, the investigators hypothesize that this modification is accompanied by neural activity changes recordable with magnetoencephalography (MEG). The primary objective of this study is to identify neural activity changes during hypnotic trance in healthy volunteers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at P25-P50 for not_applicable healthy-volunteers

Timeline
Completed

Started Dec 2019

Typical duration for not_applicable healthy-volunteers

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 21, 2019

Completed
25 days until next milestone

First Posted

Study publicly available on registry

July 16, 2019

Completed
5 months until next milestone

Study Start

First participant enrolled

December 1, 2019

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2021

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 23, 2021

Completed
Last Updated

May 18, 2022

Status Verified

May 1, 2022

Enrollment Period

1.3 years

First QC Date

June 21, 2019

Last Update Submit

May 17, 2022

Conditions

Healthy Volunteers

Keywords

HypnosisMEGAuditory Evoked Magnetic FieldsOscillatory activityNetworks

Outcome Measures

Primary Outcomes (1)

  • Neural activity changes recorded by magnetoencephalography (MEG) during hypnotic trance, in healthy volunteers.

    Oscillatory activity will be recorded by magnetoencephalography (MEG) : power averages of oscillations (delta, theta, alpha, beta and gamma) and phase values recorded during hypnotic trance will be compared to control conditions.

    2 hours

Secondary Outcomes (3)

  • Neural networks activity changes recorded by magnetoencephalography (MEG) during hypnotic trance, in healthy volunteers.

    2 hours

  • Changes in auditory evoked magnetic fields (MAEF), recorded by magnetoencephalography (MEG) during hypnotic trance, in healthy volunteers.

    2 hours

  • Cardiac and respiratory changes in link to neural activity changes observed during the hypnotic trance

    2 hours

Study Arms (1)

Right-handed healthy volunteers

EXPERIMENTAL

Magnetoencephalography (MEG) records

Behavioral: Hypnosis

Interventions

HypnosisBEHAVIORAL

several blocks of hypnosis including entry into a hypnotic state (= induction), the hypnotic trance and the exit from hypnosis (= reassociation).

Right-handed healthy volunteers

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy volunteers
  • Right-handed
  • Non-smoking
  • Major participants
  • Speaking fluent French
  • No experience of hypnosis or other forms of meditation and relaxation
  • Registered in the French social security scheme
  • Signed informed consent

You may not qualify if:

  • Contraindication to Magnetoencephalography (MEG) and/or Magnetic resonance imaging (MRI) : implanted material, claustrophobia,…
  • Treatment that may impact physiological measures (psychotropic, cardiovascular,…)
  • All categories of protected persons (Pregnant or lactating women, persons subject to a legal protection measure, persons deprived of their liberty by judicial or administrative decision)
  • Smokers
  • Persons with personality disorders or addictions / narcotic use

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Clinatec Cea/Chuga

Grenoble, 38054, France

Location

Related Publications (4)

  • De Pascalis V, Ray WJ, Tranquillo I, D'Amico D. EEG activity and heart rate during recall of emotional events in hypnosis: relationships with hypnotizability and suggestibility. Int J Psychophysiol. 1998 Aug;29(3):255-75. doi: 10.1016/s0167-8760(98)00009-9.

    PMID: 9666380BACKGROUND

  • Vanhaudenhuyse A, Laureys S, Faymonville ME. Neurophysiology of hypnosis. Neurophysiol Clin. 2014 Oct;44(4):343-53. doi: 10.1016/j.neucli.2013.09.006. Epub 2013 Oct 29.

    PMID: 25306075BACKGROUND

  • Jensen MP, Adachi T, Hakimian S. Brain Oscillations, Hypnosis, and Hypnotizability. Am J Clin Hypn. 2015 Jan;57(3):230-53. doi: 10.1080/00029157.2015.985573.

    PMID: 25928684BACKGROUND

  • Zeev-Wolf M, Dor-Ziderman Y, Goldstein A, Bonne O, Abramowitz EG. Oscillatory brain mechanisms of the hypnotically-induced out-of-body experience. Cortex. 2017 Nov;96:19-30. doi: 10.1016/j.cortex.2017.08.025. Epub 2017 Aug 31.

    PMID: 28961523BACKGROUND

MeSH Terms

Interventions

Hypnosis

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsPsychotherapyBehavioral Disciplines and Activities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 21, 2019

First Posted

July 16, 2019

Study Start

December 1, 2019

Primary Completion

April 1, 2021

Study Completion

November 23, 2021

Last Updated

May 18, 2022

Record last verified: 2022-05

Locations

FR(1)