Impact of Oral Glucose Tolerance Test on Extent of Hemoglobin Glycation

NCT04018430 | Unknown DMC

• 1 other identifier: Lmzrisch
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The glycation extent of human hemoglobin is under control of the Maillard reaction, a chemical interaction between an amino acide and a reducing sugar. About 5% ( 31.1 mmol/mol) of hemoglobin molecules secluded in a red blood cell are glycated; excessive values \> 6.5% point to prediabetes or overt diabetes mellitus. To ascertain the diagnosis doctors prescribe oral glucose tolerance upon which glucose concentrations in blood increase - how much HbA1c reacts under these circumstances is ill known.

Conditions

Blood Glucose, High; Oral Hypoglycaemic Overdose

Keywords

glucose, insulin, HbA1c

Outcome Measures

Primary Outcomes (1)

• HbA1c concentration upon oral glucose tolerance testing

  HbA1c significantly increases upon oral glucose tolerance testing

  48 hours

Eligibility Criteria

• Age: 5 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

(i) Those suspected to suffer from the metabolic syndrome including high blood pressure, high blood sugar, excess of body fat and increased cholesterol levels (ii) patients with overt impaired carbohydrate metabolisms, under treatment and tested for follow up

You may qualify if:

• apparently healthy subjects or subjects supposedly experiencing a metabolic disease (e.g. prediabetes) Subjects with asked for fasting blood glucose

You may not qualify if:

• current steroid use thyroid dysfunction (free-thyroxin levels \< 9 or \> 19 pmol/L, hsCRP \> 10 mg/L hospitalized

Sponsors & Collaborators

• Urs E. Nydegger: lead
• Labormedizinisches Zentrum Dr. Risch: collaborator

Study Sites (1)

University of Bern

Bern, Canton of Bern, 3000, Switzerland

Location

Related Publications (2)

• Medina Escobar P, Moser M, Risch L, Risch M, Nydegger UE, Stanga Z. Impaired glucose metabolism and type 2 diabetes in apparently healthy senior citizens. Swiss Med Wkly. 2015 Nov 23;145:w14209. doi: 10.4414/smw.2015.14209. eCollection 2015.

  PMID: 26594954 BACKGROUND

• Rabbani N, Ashour A, Thornalley PJ. Mass spectrometric determination of early and advanced glycation in biology. Glycoconj J. 2016 Aug;33(4):553-68. doi: 10.1007/s10719-016-9709-8. Epub 2016 Jul 20.

  PMID: 27438287 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

venous blood samples processed to yield 4 ml of blood plasma

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Urs Nydegger, MD

  Labormedizinisches Zentrum Dr. Risch

  STUDY CHAIR

Central Study Contacts

Nathalie Gilliéron, CT

CONTACT

+41(0)21 622.87.32; nathalie.gillieron@vidymed.ch

Urs Nydegger, MD

CONTACT

+41(0)58 523.34.66; urs.nydegger@risch.ch

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 20 Days
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head Hematology Senior Consultant

Study Record Dates

• First Submitted: July 10, 2019
• First Posted: July 12, 2019
• Study Start: September 1, 2019
• Primary Completion: September 30, 2020
• Study Completion: September 30, 2021
• Last Updated: July 12, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)