Ocular Function in Autism Spectrum Disorder

NCT04010422 | Unknown

• 1 other identifier: 201904121RINC
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the visual function in individuals with ASD, with a particular focus on the ocular surface condition and visual function assessment.

Conditions

Autism; Ocular Surface Disease

Outcome Measures

Primary Outcomes (2)

• cornea innervation

  The participants will undergo HRT in vivo confocal microscopy. It is a laser scanning confocal microscope, operating by scanning a 670 nm laser beam in a raster pattern over the field of view. The system uses a high numerical aperture 63x objective lens (0.9 NA), and produces images with high contrast and better axial resolution (7.6 µm) than other in vivo confocal systems (9 µm for the TSCM and 24 µm for the Confoscan). The HRT-RCM provides new built-in software for 3D imaging of the corneal structure. Quantitative imaging of the subbasal nerve plexus could be per-formed by CCMetrics system, a custom software program developed at the University of Manchester.

  30 min

• Blinking reflex

  Blinking rates manually calculated by two different research personnel and Tobii Pro X3-120 under two conditions: viewing preset film on the laptop and casual conversation with interviewer.

  30 min

Study Arms (2)

ASD group

Inclusion Criteria: 1. Having a clinical diagnosis of autism spectrum disorder 2. Aged over 20 years; able to read and sign an informed consent form. 3. Clear conscious and can follow the instruction of opening eyes and movement toward all direction. Exclusion Criteria: 1. Unable to cooperate with the examinations. 2. Younger than 20 years old

Diagnostic Test: no intervention

TD Group

Inclusion Criteria: 1. Aged over 20 years; able to read and sign an informed consent form. 2. Clear conscious and can follow the instruction of opening eyes and movement toward all direction. Exclusion Criteria: 1. Unable to cooperate with the examinations. 2. Younger than 20 years old. 3. Having a clinical diagnosis of autism spectrum disorder

Diagnostic Test: no intervention

Interventions

no intervention DIAGNOSTIC_TEST

no intervention

ASD group; TD Group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is an observation study. We will recruit 50 adults with autism spectrum disorder aging over 20 years old from the Psychiatry Department, National Taiwan University Hospital. We will also recruit 50 adults without autism spectrum disorder aging over 20 years old from the Ophthalmology Department, National Taiwan University Hospital.

You may qualify if:

• Having a clinical diagnosis of autism spectrum disorder
• Aged over 20 years; able to read and sign an informed consent form.
• Clear conscious and can follow the instruction of opening eyes and movement toward all direction.

You may not qualify if:

• Unable to cooperate with the examinations.
• Younger than 20 years old.
• TD group:
• Aged over 20 years; able to read and sign an informed consent form.
• Clear conscious and can follow the instruction of opening eyes and movement toward all direction.
• Unable to cooperate with the examinations.
• Younger than 20 years old.
• Having a clinical diagnosis of autism spectrum disorder

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Related Publications (1)

• Wu CS, Tsai HJ, Chien YL, Gau SS. All-Cause Mortality and Specific Causes of Death in Autism: A Nationwide Analysis. Autism Adulthood. 2025 Feb 5;7(1):81-92. doi: 10.1089/aut.2023.0103. eCollection 2025 Feb.

  PMID: 40151655 DERIVED

MeSH Terms

Conditions

Autistic Disorder

Condition Hierarchy (Ancestors)

Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Yi Ling Chien

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yi Ling Chien

CONTACT

886-2-2312-3456; ylchien@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 4, 2019
• First Posted: July 8, 2019
• Study Start: May 15, 2019
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: April 18, 2023

Record last verified: 2023-04

Locations

TW (1)