NCT04010409

Brief Summary

This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2019

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 8, 2019

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

July 4, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 8, 2019

Completed
5.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
Last Updated

April 18, 2023

Status Verified

December 1, 2022

Enrollment Period

6 years

First QC Date

July 4, 2019

Last Update Submit

April 13, 2023

Conditions

Autism Spectrum Disorder

Outcome Measures

Primary Outcomes (1)

  • eye tracking indicators

    eye tracking indicators

    30 min

Study Arms (2)

ASD Group

Autism spectrum disorder participants, no intervention

Other: no intervention

TD Group

Typically developmental controls,no intervention

Other: no intervention

Interventions

no interventionOTHER

no intervention

ASD GroupTD Group

Eligibility Criteria

Age20 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

The 30 adults with ASD will be recruited from Adult ASD clinics in Department of Psychiatry, National Taiwan University Hospital.

You may qualify if:

  • Adult aged between 20 and 50 years who had a diagnosis of ASD based on DSM-5.
  • Had a full-scale IQ \> 70 on WAIS-IV.

You may not qualify if:

  • A history of major mental illness (e.g., bipolar affective disorder, schizophrenia) or neurological diseases.
  • Visual impairment and that would preclude participation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Related Publications (1)

  • Chien YL, Tseng YL, Tsai WC, Chiu YN. Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS. J Autism Dev Disord. 2025 May;55(5):1648-1659. doi: 10.1007/s10803-024-06306-5. Epub 2024 Apr 18.

    PMID: 38635133DERIVED

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, PervasiveNeurodevelopmental DisordersMental Disorders

Study Officials

  • Yi Ling Chien, M.D., Ph.D.

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yi Ling Chien, M.D., Ph.D.

CONTACT

886-2-2312-3456ylchien@hotmail.com

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 4, 2019

First Posted

July 8, 2019

Study Start

January 8, 2019

Primary Completion

December 31, 2024

Study Completion

December 31, 2024

Last Updated

April 18, 2023

Record last verified: 2022-12

Locations

TW(1)