Effect of Date Seeds Coffee on Mood and Cognitive Performance

NCT04009564 | Completed

• 1 other identifier: DSCPM
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Limited utilizations of date seeds have previously been explored, and so previously wastage has often been the normality. However, research now indicates that several fruit seeds contain higher concentrations of beneficial total phytochemicals within their seeds in comparison to the flesh. As well as high nutritional values of date seeds for fibre, protein and micronutrients, this increased phytochemical content has been proven to be true for date seeds, with mainly phenolic acids (24.6 g k GAE) 3 and total flavonoids (3.67 g k RE). With the seeds presently being used to produce new coffee products, it raises questions on whether consumption of date seeds can alter mood and cognitive behaviour and therefore research into investigate the acute effect of date seeds coffee on mood and cognitive function on healthy young volunteers. However, to the best of the research team knowledge, this is the first human trial to investigate these effects.

Conditions

Health Status

Outcome Measures

Primary Outcomes (1)

• The average of the change in 9 cognitive indexes including: Attentional Intensity, Sustained Attention, Attentional Fluctuation, Memory Retrieval Speed, Cognitive Reaction Time, Working Memory Capacity, Episodic Memory Capacity, Quality of Memory

  Cog-track an online set of nine cognitive tests (www.wesnes.com).

  Change from baseline at 45 minutes post dose and at 90 minutes post dose for each visit

Secondary Outcomes (3)

• Change in Caffeine consumption using caffeine consumption questionnaire

  Change form Baseline for each visit only

• Caffeine research Visual Analogue Scales

  Change from baseline 45 minutes post dose and at 90 minutes post dose.

• Change in Mood using Bond Lader Visual Analogue Scales

  Change from baseline 45 minutes post dose and at 90 minutes post dose.

Study Arms (3)

Date seeds filtered coffee

EXPERIMENTAL

Each participant will consume this arm in a visit has been allocated by Latin Square randomisation order: 45 g of date seeds coffee in 280 ml of boiled water, coffee flavour and brown food colouring ( made using a filter coffee machine). it will be served in a paper cup with lid

Dietary Supplement: Date coffee

Normal filtered coffee

EXPERIMENTAL

Each participant will consume this arm in a visit has been allocated by Latin Square randomisation order: 6 g of coffee in 280 ml of boiled water (made using a filter coffee machine) it will be served in a paper cup with lid

Dietary Supplement: Normal coffee

Placebo

PLACEBO COMPARATOR

Each participant will consume this arm in a visit has been allocated by Latin Square randomisation order: 280 of boiled water, coffee flavour and brown food colouring it will be served in a paper cup with lid

Dietary Supplement: Placebo

Interventions

Date coffee DIETARY_SUPPLEMENT

45 g of date seeds coffee in 280 ml of water

Date seeds filtered coffee

Normal coffee DIETARY_SUPPLEMENT

6 g of normal coffee in 280ml of water

Normal filtered coffee

Placebo DIETARY_SUPPLEMENT

water, food colouring and coffee flavouring

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy young volunteers age between 18 to 35

You may not qualify if:

• Participants will be ineligible to participate in the study if any of the following apply:
• Have a BMI above 35kg/m2
• Smokers or tobacco product consumers which includes electronic cigarettes
• Are taking any illicit or prescribed drugs.
• Have a history of, or currently, abuse alcohol
• Have a history of dyslexia, ADHD, learning difficulties or colour blindness,
• Females who are pregnant, lactating or seeking to become pregnant, or are at risk of pregnancy as they to do not use birth control measures
• Have allergies to any food product.

Sponsors & Collaborators

• Newcastle University: lead

Study Sites (1)

NU-Food Research Facility

Newcastle upon Tyne, Tyne and Wear, NE1 7RU, United Kingdom

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 19, 2018
• First Posted: July 5, 2019
• Study Start: June 20, 2019
• Primary Completion: March 7, 2020
• Study Completion: March 30, 2020
• Last Updated: August 31, 2020

Record last verified: 2019-07

Locations

GB (1)