The Effects of Resveratrol Supplementation on Inflammation and Cognitive Performance in Healthy Adults

NCT04314739 | Completed

• 1 other identifier: 52P7
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Previous research has suggested that high levels of systemic inflammation can contribute to cognitive deficits and additional health problems; consumption of polyphenols have been shown to have an anti-inflammatory effect. Resveratrol, a polyphenol found primarily in red grape skins, has previously been shown to improve brain blood flow and possibly brain function and may potentially reduce systemic inflammation, however there is limited research into this. This study will investigate the effects of 4 weeks daily consumption of resveratrol on inflammation and cognitive function in healthy adults.

Conditions

Cognitive Change; Mood; Systemic Inflammation

Keywords

Resveratrol; Polyphenol; Cognition; Mood; Inflammation

Outcome Measures

Primary Outcomes (1)

• Change from baseline concentration of biomarkers of systemic inflammation

  Assessment of change from baseline: C reactive protein, tumor necrosis factor alpha and interleukin 6.

  1 hour post dose; 4 weeks

Secondary Outcomes (11)

• Acute changes in cognitive task performance

  40 minutes post dose

• Interim changes in cognitive task performance

  Day 7; Day 14; Day 21; Day 28

• Chronic changes in cognitive task performance

  4 weeks

• Acute changes in mood

  40 mins post dose

• Interim changes in mood

  Day 7; Day 14; Day 21; Day 28

Study Arms (2)

Resveratrol

ACTIVE COMPARATOR

500mg of Veri-te Resveratrol (consumed as two 250mg tablets, at two timepoints each day).

Dietary Supplement: Resveratrol

Placebo

PLACEBO COMPARATOR

Matched placebo capsules (1 capsule consumed at two timepoints each day).

Dietary Supplement: Placebo

Interventions

Resveratrol DIETARY_SUPPLEMENT

Participants will consume one of the treatment types daily for a period of four weeks.

Also known as: Veri-teTM Resveratrol

Resveratrol

Placebo DIETARY_SUPPLEMENT

Participants will consume one of the treatment types daily for a period of four weeks.

Placebo

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants must self-assess themselves as being in good health.
• Aged 18 to 55 at the time of giving consent

You may not qualify if:

• Have a Body Mass Index (BMI) outside the range of 18.5-42kg/m2

Sponsors & Collaborators

• Northumbria University: lead
• Evolva SA: collaborator

Study Sites (1)

Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Location

MeSH Terms

Conditions

Inflammation

Interventions

Resveratrol

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Stilbestrols; Stilbenes; Benzylidene Compounds; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Polyphenols; Phenols

Study Officials

• Emma L Wightman, Dr

  Northumbria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2019
• First Posted: March 19, 2020
• Study Start: March 19, 2019
• Primary Completion: December 19, 2019
• Study Completion: December 19, 2019
• Last Updated: March 19, 2020

Record last verified: 2019-03

Locations

GB (1)