NCT04006756|CompletedDMC
A Study on Better Cognitive Functioning Through Braintraining on the Internet
BrainFit
BrainFit: The Effect of Online Cognitive Training in Patients With Late Life Mood Disorders.
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BrainFit
BrainFit: The Effect of Online Cognitive Training in Patients With Late Life Mood Disorders.
Sponsor study identifier
interventional
38
1 country
1
Study Start
September 17, 2019
Actual (reported)Primary Completion
November 11, 2021
Actual (reported)Study Completion
November 11, 2021
Actual (reported)This study evaluates the efficacy of an eight-week online cognitive training program on feasability and on objective and subjective cognitive functions in patients with late life mood disorders (LLMD). In the feasability study two training groups will be compared. The primary aim is to investigate feasability, measured by compliance attendance and satisfaction of the participants. The secondary aim is to study the possible effects of the intervention on cognitive functions. Additionally, effects on mood symptoms, social functioning, sense of mastery and quality of lide will be studied.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 11, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 12, 2019
Actual (reported)July 5, 2019
Actual (reported)September 17, 2019
Actual (reported)November 11, 2021
Actual (reported)November 11, 2021
Actual (reported)Feasability of the intervention measured via therapy compliance and drop-out
therapy compliance, drop-out
Eight weeks (T1)
Appreciation of the intervention
Questionnaire on difficulty, feasability, joy, effort, challenge of the therapy, clearness of the intervention explanation, evaluation groups (mirror groups)
Eight weeks (T1)
Subjective cognitive functioning measured via the CFQ
Eight weeks (T1) and 3 months (T2)
Eight-week, three times a week during 45 minutes cognitive training
Eight-week, three times a week during 45 minutes cognitive activities
Eight-week online cognitive training program, three times a week for 45 minutes. The training contains several games that are designed to train cognitive functions.
Eight-week online active comparator program, three times a week for 45 minutes. The training contains several games.
GGZ inGeest
Amsterdam, North Holland, 1081 JC, Netherlands
Depp C, Vahia IV, Jeste D. Successful aging: focus on cognitive and emotional health. Annu Rev Clin Psychol. 2010;6:527-50. doi: 10.1146/annurev.clinpsy.121208.131449.
Farrand P, Matthews J, Dickens C, Anderson M, Woodford J. Psychological interventions to improve psychological well-being in people with dementia or mild cognitive impairment: systematic review and meta-analysis protocol. BMJ Open. 2016 Jan 27;6(1):e009713. doi: 10.1136/bmjopen-2015-009713.
Annemiek Dols, MD, PhD
Amsterdam UMC, location VUmc
Mardien Oudega, MD, PhD
Amsterdam UMC, location VUmc
38 participants (actual enrollment reported by the registry).
First Submitted
February 12, 2019
First Posted
July 5, 2019
Study Start
September 17, 2019
Actual (reported)Acceptability and Clinical, Cognitive and Brain Efficacy of the Pilot of a Computerized Psychotherapy Program Based on Behavioural and Cognitive Techniques in the Depressed Patient
Genaral objective cognitive functioning via the MOCA
Eight weeks (T1) and 3 months (T2)
Mood symptoms via MADRS
Eight weeks (T1) and 3 months (T2)
Quality of life via the MANSA
Eight weeks (T1) and 3 months (T2)
Sense of Mastery via Mastery questionnaire
Eight weeks (T1) and 3 months (T2)
Apathy via apathy scale
Eight weeks (T1) and 3 months (T2)
Global cognitive dysfunction via the Pentagon Drawing Test
Eight weeks (T1) and 3 months (T2)
Information processing speed and inhibition via the STROOP-test
Eight weeks (T1) and 3 months (T2)
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Harris Y, Cooper JK. Depressive symptoms in older people predict nursing home admission. J Am Geriatr Soc. 2006 Apr;54(4):593-7. doi: 10.1111/j.1532-5415.2006.00687.x.
Korten NC, Penninx BW, Kok RM, Stek ML, Oude Voshaar RC, Deeg DJ, Comijs HC. Heterogeneity of late-life depression: relationship with cognitive functioning. Int Psychogeriatr. 2014 Jun;26(6):953-63. doi: 10.1017/S1041610214000155. Epub 2014 Feb 24.
Kuiper JS, Zuidersma M, Zuidema SU, Burgerhof JG, Stolk RP, Oude Voshaar RC, Smidt N. Social relationships and cognitive decline: a systematic review and meta-analysis of longitudinal cohort studies. Int J Epidemiol. 2016 Aug;45(4):1169-1206. doi: 10.1093/ije/dyw089. Epub 2016 Jun 6.
Motter JN, Pimontel MA, Rindskopf D, Devanand DP, Doraiswamy PM, Sneed JR. Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis. J Affect Disord. 2016 Jan 1;189:184-91. doi: 10.1016/j.jad.2015.09.022. Epub 2015 Sep 26.
Preiss M, Shatil E, Cermakova R, Cimermanova D, Ram I. Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Front Hum Neurosci. 2013 May 13;7:108. doi: 10.3389/fnhum.2013.00108. eCollection 2013.
Radua J, Grunze H, Amann BL. Meta-Analysis of the Risk of Subsequent Mood Episodes in Bipolar Disorder. Psychother Psychosom. 2017;86(2):90-98. doi: 10.1159/000449417. Epub 2017 Feb 10.
Schouws SN, Stek ML, Comijs HC, Dols A, Beekman AT. Cognitive decline in elderly bipolar disorder patients: a follow-up study. Bipolar Disord. 2012 Nov;14(7):749-55. doi: 10.1111/bdi.12000. Epub 2012 Sep 21.
Spijker, J., Bockting, C.L.H., Meeuwissen, J.A.C., et al. (2013) Dutch Multidisciplinary guideline for Depression: Trimbos Institute.
Strohle A, Schmidt DK, Schultz F, Fricke N, Staden T, Hellweg R, Priller J, Rapp MA, Rieckmann N. Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials. Am J Geriatr Psychiatry. 2015 Dec;23(12):1234-1249. doi: 10.1016/j.jagp.2015.07.007. Epub 2015 Jul 21.
van der Stel JC. [Functional recovery and self-regulation: assignments for both clients and psychiatrists]. Tijdschr Psychiatr. 2015;57(11):815-22. Dutch.
van Liempt S, Dols A, Schouws S, Stek ML, Meesters PD. Comparison of social functioning in community-living older individuals with schizophrenia and bipolar disorder: a catchment area-based study. Int J Geriatr Psychiatry. 2017 May;32(5):532-538. doi: 10.1002/gps.4490. Epub 2016 Apr 27.
Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, Morris JN, Rebok GW, Unverzagt FW, Stoddard AM, Wright E; ACTIVE Study Group. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA. 2006 Dec 20;296(23):2805-14. doi: 10.1001/jama.296.23.2805.
Yliruka, L. (2012) 'The Mirror Method: a structure supporting expertise in social welfare services.', Social Work & Social Sciences Review., 15(2), pp. 9-37.
Oudega ML, Wagenmakers MJ, Palsma T, Hoogendoorn AW, Vriend C, van den Heuvel OA, Schouws S, Dols A. BrainFit: improving executive and subjective cognitive functioning in late-life mood disorders - a double-blind randomized active-controlled study evaluating the effect of online cognitive training. Front Psychiatry. 2025 Jan 2;15:1509821. doi: 10.3389/fpsyt.2024.1509821. eCollection 2024.
Primary Completion
November 11, 2021
Actual (reported)Study Completion
November 11, 2021
Actual (reported)Last Updated
December 1, 2021
Record last verified: 2021-11
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