CHANGE
Behavioral Economic Incentives to Improve Medication Adherence and Outcomes Among Patients in United States With HIV: A Feasibility Study
Sponsor study identifier
interventional
40
1 country
1
Study Start
May 16, 2019
Actual (reported)Primary Completion
September 27, 2019
Actual (reported)Study Completion
October 13, 2020
Actual (reported)With support from the NIH, this pilot study will assess the feasibility of using wireless devices and financial incentives to motivate medication adherence among HIV-positive adults in the U.S., focusing on those with non-suppressed viral loads. While daily lotteries using wireless devices may have great potential for improving adherence to ART regimens, substantial questions exist as to whether it is: 1) possible to achieve high rates of uptake for a pilot offering wireless devices to high-risk populations; 2) achieve high rates of sustained engagement.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 13, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 16, 2019
Actual (reported)May 23, 2019
Actual (reported)June 24, 2019
Actual (reported)September 27, 2019
Actual (reported)October 13, 2020
Actual (reported)Number of patients with viral suppression
viral load less than 400
approximately 3 months after enrollment
viral suppression by arm
approximately 3 months after enrollment
medication adherence by arm
approximately 3 months after enrollment
Recruitment rates by arm
approximately 3 months after enrollment
Attrition rates by arm
approximately 3 months after enrollment
Percent of patients that use electronic pill bottle
approximately 3 months after enrollment
Participants randomized to this arm will receive an electronic pill bottle, AdhereTech. The AdhereTech bottle will be remotely monitored by the Way to Health platform. Participants will be randomly assigned a 2-digit number to be used as part of the lottery-based engagement incentives in which eligibility to win will be conditional on medication adherence. Participants will also be eligible for a financial bonus if participant's viral load is suppressed at the end of the intervention period. Participants will also receive an enrollment incentive and an incentive to complete a lab visit at the end of the intervention period.
Of the 20 participants randomized to the control arm, 10 will be randomly assigned to receive an electronic pill bottle, AdhereTech. The AdhereTech bottle will be remotely monitored by the Way to Health platform. Participants will also receive an enrollment incentive and an incentive to complete a lab visit at the end of the intervention period.
Provision of wireless devices and financial incentives to motivate medication adherence among HIV-positive adults who have not reached viral suppression.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Drexel University
Philadelphia, Pennsylvania, 19104, United States
Bien-Gund CH, Ho JI, Bair EF, Marcus N, Choi RJ, Szep Z, Althoff A, Momplaisir FM, Thirumurthy H. Brief Report: Financial Incentives and Real-Time Adherence Monitoring to Promote Daily Adherence to HIV Treatment and Viral Suppression Among People Living With HIV: A Pilot Study. J Acquir Immune Defic Syndr. 2021 May 1;87(1):688-692. doi: 10.1097/QAI.0000000000002628.
40 participants (actual enrollment reported by the registry).
First Submitted
May 23, 2019
First Posted
June 24, 2019
Study Start
WelTelOAKTREE: Text Messaging to Support Patients With HIV/AIDS in British Columbia
Contact the study team to confirm eligibility.
May 16, 2019
Actual (reported)Primary Completion
September 27, 2019
Actual (reported)Study Completion
October 13, 2020
Actual (reported)Last Updated
October 19, 2020
Record last verified: 2020-10
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Source: ClinicalTrials.gov.
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