Ovarian Reserve and Embryo Implantation

NCT03989921 | Completed

• 1 other identifier: Local/2018/OP-01
• Study Type: observational
• Target: 598
• Locations: 1 country
• Sites: 1

Brief Summary

Compare, in young patients with In vitro fertilization (IVF), the rate of embryo implantation by early culture transfer (J2-J3) between 2 groups of patients: "normo responders" vs. "poor responders".

Conditions

Ovarian Reserve; IVF

Outcome Measures

Primary Outcomes (1)

• The embryo implantation rate at 5 weeks after transfer is defined by the presence of an embryo with objective cardiac activity by ultrasound

  The embryo implantation rate corresponds to the number of embryos with cardiac activity found on the number of embryos transferred

  5weeks

Study Arms (2)

normo responders

that have an AMH dosage greater than or equal to 1.2 ng/mL

Other: no intervention. observational study

poor responders

with a dosage of less than 1.2 ng/mL

Other: no intervention. observational study

Interventions

no intervention. observational study OTHER

no intervention. observational study

normo responders; poor responders

Eligibility Criteria

• Age: 35 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The population concerned is all young patients, defined as being under 35 years old, who have benefited from IVF in the 2 inclusion centres (Centres d'Aide Médicale à la Procréation des CHU de Nîmes and the Saint Roch clinic in Montpellier) between 01/01/2014 and 30/06/2015.

You may qualify if:

• IVF patient managed with or without ICSI between 01/01/2014 and 30/06/2015 in one of the two study centres
• Age \< 35 years old
• Fresh transfer of at least one embryo between D2 and D6
• patients who have already received one or more transfer attempts.

You may not qualify if:

• No fresh transfer (Freeze All, segmentation failure, stimulation failure)
• Double successive embryo transfer (e. g. J3-J5). We did not retain these cases because if only one of the 2 embryos is implanted, it is not possible to know which transfer it corresponds to.
• Maternal serum FSH determination \< 4 IU/ml at D3 in the baseline balance sheet (hypogonadotropic hypogonadism)

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHUNimes

Nîmes, France

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2019
• First Posted: June 18, 2019
• Study Start: November 29, 2018
• Primary Completion: April 30, 2019
• Study Completion: April 30, 2019
• Last Updated: June 18, 2019

Record last verified: 2019-06

Locations

FR (1)