NCT03979885

Brief Summary

Financial incentives for motivating changes in health behavior, particularly for smoking and other morbid habits, are increasingly being tested by health insurers, employers, and government agencies. However, in using incentive programs for smoking cessation, key unanswered structural and theoretical questions remain regarding their effectiveness, acceptability to patients, and economic sustainability. This trial aims to advance the science and implementation of financial incentives for smoking cessation interventions among high-risk, hospitalized smokers. The investigators will pursue two specific aims: 1) comparing the impact of three approaches for smoking cessation on smoking abstinence, use of evidenced-based therapy, and quality of life and 2) comparing the short-term and long term return on investment of using goal directed and outcome-based financial incentives to promote smoking cessation.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,058

participants targeted

Target at P75+ for not_applicable

Timeline
14mo left

Started Jan 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress85%
Jan 2020Jun 2027

First Submitted

Initial submission to the registry

June 4, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 7, 2019

Completed
7 months until next milestone

Study Start

First participant enrolled

January 6, 2020

Completed
5.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 7, 2025

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2027

Expected
Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

5.3 years

First QC Date

June 4, 2019

Last Update Submit

April 23, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Smoking abstinence assessed by self-report and biochemically verified by salivary cotinine

    Assessed by self-report questionnaire, and biochemically verified by salivary cotinine

    6 months

Secondary Outcomes (4)

  • Use of evidence based treatment (e.g. counseling and smoking cessation medications) assessed by discharge prescriptions, Quitline records, receipts, letters and/or self-report

    2 months

  • Quality of life as measured by PROMIS-29 Profile v2.0

    12 months

  • Short term return on investment of using financial incentives to promote smoking cessation (Cost analysis)

    12 months

  • Long term return on investment of using financial incentives to promote smoking cessation (Cost analysis)

    3 years

Study Arms (3)

Goal-Directed Incentives

OTHER
Behavioral: Smoking cessation counseling (Quitline)Behavioral: Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy)Behavioral: Financial incentives for use of evidence-based smoking cessation therapies

Outcome-Based Incentives

OTHER
Behavioral: Smoking cessation counseling (Quitline)Behavioral: Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy)Behavioral: Financial incentives for smoking cessation

Enhanced Usual Care

OTHER
Behavioral: Smoking cessation counseling (Quitline)Behavioral: Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy)

Interventions

Quitline offers community-based counseling session with a cessation counselor.

Enhanced Usual CareGoal-Directed IncentivesOutcome-Based Incentives

Participants will be encouraged to speak to their doctors about using highly effective pharmacotherapies for smoking cessation.

Enhanced Usual CareGoal-Directed IncentivesOutcome-Based Incentives

Participants will receive financial incentives for bioconfirmed smoking cessation.

Outcome-Based Incentives

Participants will receive financial incentives for the use of evidence-based smoking cessation therapies including Quitline counseling, community-based smoking cessation programs and pharmacotherapies

Goal-Directed Incentives

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age ≥ 18 years
  • smoked tobacco during the prior 30 days,
  • have an active U.S. phone number and address,
  • can provide consent in English or Spanish and
  • are in at least the contemplative stage of change for quitting smoking, as assessed by a single measure, readiness to quit

You may not qualify if:

  • use only smokeless tobacco,
  • are pregnant or breastfeeding,
  • are discharged to an institution (e.g., nursing home, long-term care facility),
  • are unable to provide informed consent, or do not have cognitive ability to enroll or participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

David Geffen School of Medicine

Los Angeles, California, 90095, United States

Location

NYU Langone Health

New York, New York, 10016, United States

Location

Related Publications (1)

  • Wali S, Gaitonde A, Sherman S, Min N, Pesantes A, Bidgoli A, Shirley A, Tseng CH, Ladapo J. Goal-directed versus outcome-based financial incentives for smoking cessation among low-income, hospitalised patients: rationale and design of the Financial Incentives for Smoking Treatment II (FIESTA II) randomised controlled trial. BMJ Open. 2023 Sep 29;13(9):e074354. doi: 10.1136/bmjopen-2023-074354.

MeSH Terms

Conditions

Smoking CessationTobacco Use Cessation

Interventions

Nicotine Replacement Therapy

Condition Hierarchy (Ancestors)

Health BehaviorBehavior

Intervention Hierarchy (Ancestors)

Drug TherapyTherapeutics

Study Officials

  • Joseph Ladapo, MD, PhD

    University of California, Los Angeles

    PRINCIPAL INVESTIGATOR
  • Scott Sherman, MD

    NYU Langone Health

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 4, 2019

First Posted

June 7, 2019

Study Start

January 6, 2020

Primary Completion

April 7, 2025

Study Completion (Estimated)

June 30, 2027

Last Updated

April 29, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

UCLA is committed to the ideals of collaborative research and adheres to the sponsors Grant Policy on Sharing of Unique Research Resources. Requests for research resources generated as part of this project will be distributed in a timely manner. Publication of data shall occur during or at the end of the project, consistent with normal scientific practices. Research data that documents, supports and validates research findings will be made available after the main findings from the final research data set have been accepted for publication. Data will be redacted to prevent the disclosure of personal identifiers.

Locations