Management of Paroxystic Atrial Fibrillation in French Intensive Care Units

NCT03977883 | Completed

• 1 other identifier: PAF-ICU - RNI 2018 CONSTANTIN
• Study Type: observational
• Target: 742
• Locations: 1 country
• Sites: 32

Brief Summary

The primary purpose of the study is to evaluate treatment of new onset atrial fibrillation in french ICU.

Conditions

New Onset Atrial Fibrillation; ICU Patients

Keywords

New onset atrial fibrillation; Paroxystic atrial fibrillation; ICU patients; Rate control; Rhythm control

Outcome Measures

Primary Outcomes (1)

• Management of Atrial Fibrillation

  All types of therapeutics used to manage atrial fibrillation are collected

  ICU stay (until 28 days)

Secondary Outcomes (7)

• Cardiac rhythm status

  Before, 5 minutes, 30 minutes, 1 hour, and 24 hours after atrial fibrillation

• Blood pressure

  Before, 5 minutes, 30 minutes, 1 hour, and 24 hours after atrial fibrillation

• Heart rate

  Before, 5 minutes, 30 minutes, 1 hour, and 24 hours after atrial fibrillation

• Cardiac output

  Before, 5 minutes, 30 minutes, 1 hour, and 24 hours after atrial fibrillation

• ScvO2

  Before, 5 minutes, 30 minutes, 1 hour, and 24 hours after atrial fibrillation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in French ICU

You may qualify if:

• Age \> 18 years
• Patient hospitalized in ICU
• New onset atrial fibrillation

You may not qualify if:

• Age \< 18 years
• Parturient or breast-feeding woman
• Persistent or permanent atrial fibrillation
• Patients after cardiovascular or thoracic surgery
• Patients with therapeutic limitations

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead
• French Society of Anesthesia and Intensive Care Medecine: collaborator

Study Sites (32)

CHU

Amiens, France

Location

CHU

Angers, France

Location

CH

Argenteuil, France

Location

CHU

Besançon, France

Location

CHU

Bordeau, France

Location

CH

Bourgoin, France

Location

Hôpital d'Instruction des Armées

Brest, France

Location

CH

Cholet, France

Location

CHU

Clermont-Ferrand, France

Location

CH

Dax, France

Location

CHU

Dijon, France

Location

CH

Eaubonne, France

Location

CHU

Grenoble, France

Location

CHU

Lille, France

Location

Hôpital du Scorff

Lorient, France

Location

APHM

Marseille, France

Location

Hôpital Saint-Joseph

Marseille, France

Location

La Timone APHM

Marseille, France

Location

Institut Régional du Cancer de Montpellier

Montpellier, France

Location

CHU

Nancy, France

Location

CHU

Nantes, France

Location

CHU

Nice, France

Location

Clinique médicale les Sources

Nice, France

Location

CHU

Nîmes, France

Location

Groupe Hospitalier Saint Joseph

Paris, France

Location

Hôpital Bichat

Paris, France

Location

Hôpital Henri Mondor

Paris, France

Location

Hôpital La Pitié Salpêtrière

Paris, France

Location

Hôpital Saint-Louis

Paris, France

Location

CHU

Rennes, France

Location

CHU

Saint-Etienne, France

Location

CHU

Toulouse, France

Location

Related Publications (1)

• Pardo E, Futier E, Muller L, Besch G, Vardon-Bounes F, Kipnis E, Lasocki S, Ledochowski S, Ochin E, Bourenne J, Grillet G, Auvet A, Mekontso Dessap A, Bruel C, Launey Y, Fiorillo M, Jabaudon M, Godet T, Mulliez A, Constantin JM; SFAR Research Network. Management of new-onset atrial fibrillation in critically ill patients: A national multicenter prospective cohort. Anaesth Crit Care Pain Med. 2025 Sep 26;45(1):101617. doi: 10.1016/j.accpm.2025.101617. Online ahead of print.

  PMID: 41016469 DERIVED

Study Officials

• Jean-Michel Constantin

  Réa Adulte CHU Clermont-Ferrand

  STUDY DIRECTOR

• Bernard Cosserant

  Neuro-Réa CHU Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

• Raiko Blondonnet

  RMC CHU Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

• Eric Kipnis

  CHU Lille

  PRINCIPAL INVESTIGATOR

• Jonathan Paillot

  CHU Besancçon

  PRINCIPAL INVESTIGATOR

• Charles Vidal

  CHU de la Réunion

  PRINCIPAL INVESTIGATOR

• Laurent Muller

  CHU Nimes

  PRINCIPAL INVESTIGATOR

• Johann Auchabie

  CH Cholet

  PRINCIPAL INVESTIGATOR

• Guillaume Grillet

  CH Lorient

  PRINCIPAL INVESTIGATOR

• Philippe Seguin

  CHU Rennes

  PRINCIPAL INVESTIGATOR

• Philippe Guerci

  CHRU Nancy

  PRINCIPAL INVESTIGATOR

• Bernard Lalanne

  Hôpital Saint-Joseph - Marseille

  PRINCIPAL INVESTIGATOR

• Marc Leone

  Hôpital Nord - APHM

  PRINCIPAL INVESTIGATOR

• Stanislas Ledochowski

  CH Bourgoin-Jallieu

  PRINCIPAL INVESTIGATOR

• Matthieu Legrand

  Hôpital Saint-Louis - APHP

  PRINCIPAL INVESTIGATOR

• Jeremy Bourenne

  La Timone APHM

  PRINCIPAL INVESTIGATOR

• Michel Durand

  University Hospital, Grenoble

  PRINCIPAL INVESTIGATOR

• Antoine Monsel

  La Pitié Sapêtrière

  PRINCIPAL INVESTIGATOR

• Mathieu Guilbart

  CHU Amiens

  PRINCIPAL INVESTIGATOR

• Matthieu Biais

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

• Cédric Bruel

  CH Saint-Joseph Paris

  PRINCIPAL INVESTIGATOR

• Antoine Roquilly

  Nantes University Hospital

  PRINCIPAL INVESTIGATOR

• Gaëtan Plantefeve

  CH Argenteuil

  PRINCIPAL INVESTIGATOR

• Jérôme Morel

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

• Carole Ichai

  CHU NICE

  PRINCIPAL INVESTIGATOR

• Adrien Auvet

  CH Dax

  PRINCIPAL INVESTIGATOR

• Enora Atchade

  Hôpital Bichat

  PRINCIPAL INVESTIGATOR

• Sigismond Lasocki

  University Hospital, Angers

  PRINCIPAL INVESTIGATOR

• Pierre-Eric Danin

  Clinique Les Sources Nice

  PRINCIPAL INVESTIGATOR

• Marc Danguy Des Deserts

  Hôpital d'Instruction des Armées de Brest

  PRINCIPAL INVESTIGATOR

• Evelina Ochin Salatova

  Hôpital Simone Veil - CH d'Eaubonne

  PRINCIPAL INVESTIGATOR

• Antoine Rouget

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

• Armand Mekontso Dessap

  Hôpital Henri Mondor APHP

  PRINCIPAL INVESTIGATOR

• Justine Perrot

  CHU Dijon

  PRINCIPAL INVESTIGATOR

• Jibba Amraoui

  Institut Régional du Cancer de Montpellier

  PRINCIPAL INVESTIGATOR

• Matthias Garot

  CHU Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2019
• First Posted: June 6, 2019
• Study Start: May 13, 2019
• Primary Completion: August 27, 2020
• Study Completion: August 27, 2020
• Last Updated: August 25, 2021

Record last verified: 2021-08

Locations

FR (32)