New-Onset Atrial Fibrillation Complicating Acute Myocardial Infarction in China

NCT05511649 | Completed DMC

• 1 other identifier: NOAFCAMI-China
• Study Type: observational
• Target: 832
• Locations: 1 country
• Sites: 3

Brief Summary

To investigate the prognostic impacts of the atrial fibrillation burden (AFb) in acute myocardial infarction (AMI) patients who developed paroxysmal new-onset atrial fibrillation (NOAF) during the index AMI hospitalization.

Conditions

New Onset Atrial Fibrillation; Acute Myocardial Infarction

Keywords

myocardial infarction; new-onset atrial fibrillation; atrial fibrillation burden; mortality

Outcome Measures

Primary Outcomes (1)

• All-cause death

  Death from any cause

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

Secondary Outcomes (5)

• Cardiovascular death

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

• Recurrent myocardial infarction

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

• Heart failure hospitalization

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

• Ischemic stroke

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

• Major bleeding

  From the time of AMI discharge until occurrence of an outcome of interest, death, or loss to follow up, maximum up to 10 years

Study Arms (2)

Post-MI NOAF with low AF burden

Patients with post-MI NOAF who had a AF burden\<10.87%. The cut-off value of AF burden of 10.87% was identified based on our previous work.

Device: continuous electronic monitor

Post-MI NOAF with high AF burden

Patients with post-MI NOAF who had a AF burden≥10.87%.

Device: continuous electronic monitor

Interventions

continuous electronic monitor DEVICE

All patients with MI hospitalized in the CCU department of Shanghai Tenth People's Hospital, KaiFeng Central Hospital, and the First Affiliated Hospital of Zhengzhou University will receive 24-hour continuous cardiac monitoring until discharge.

Also known as: Philips IntelliVue MP40, Netherlands

Post-MI NOAF with high AF burden; Post-MI NOAF with low AF burden

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with post-MI NOAF

You may qualify if:

• Patients hospitalized for AMI including both STEMI and NSTEMI between January 2014 and January 2022 at the CCU department of Shanghai Tenth People's Hospital, KaiFeng Central Hospital, and the First Affiliated Hospital of Zhengzhou University.
• Patients who developed a first documented AF (NOAF) during the index AMI hospitalization；
• Adult patients (\>18 years old).

You may not qualify if:

• Patients with a medical history of pre-existing AF;
• Patients with a medical history of rheumatic valvular disease;
• Patients with a medical history of sick sinus syndrome;
• Patients undergoing emergent coronary artery bypass surgery;
• Patients' medical records with serious deficiencies and CEM data cannot be retrieved;

Sponsors & Collaborators

• Shanghai 10th People's Hospital: lead
• Kaifeng Central Hospital: collaborator
• The First Affiliated Hospital of Zhengzhou University: collaborator

Study Sites (3)

KaiFeng Central Hospital

Kaifeng, Henan, China

Location

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Location

Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, 200072, China

Location

Related Publications (2)

• Luo J, Qin X, Yuan Y, Zhang Y, Liu J, Wang Y, Zhao G, Xiao L, Zhang X, Fang Y, Shi W, Qin L, Liu B, Wei Y; NOAFCAMI-China Registry Investigators. Association of Atrial Fibrillation Burden With Cardiovascular Outcomes in New-Onset Atrial Fibrillation Complicating Myocardial Infarction. J Am Heart Assoc. 2025 May 20;14(10):e039547. doi: 10.1161/JAHA.124.039547. Epub 2025 Apr 16.

  PMID: 40240944 RESULT

• Luo J, Qin X, Fang Y, Zhang X, Zhang Y, Liu J, Wang Y, Zhao G, Xiao L, Shi W, Qin L, Liu B, Wei Y. Development and external validation of a prognostic model for new-onset atrial fibrillation complicating acute myocardial infarction: insights from the NOAFCAMI-China registry. Eur Heart J Acute Cardiovasc Care. 2026 Mar 10;15(1):32-41. doi: 10.1093/ehjacc/zuaf122.

  PMID: 40974091 RESULT

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Yidong Wei, M.D., Ph.D.

  Shanghai 10th People's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician

Study Record Dates

• First Submitted: August 20, 2022
• First Posted: August 23, 2022
• Study Start: March 1, 2023
• Primary Completion: July 27, 2023
• Study Completion: September 23, 2023
• Last Updated: March 19, 2026

Record last verified: 2026-03

Locations

CN (3)