Translating Neuroscience to Population Health

NCT03976427 | Completed

• 1 other identifier: STUDY00142526
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The current study will examine the relationship between brain responses and a guided imagery exercise in overweight and obese individuals. Results of this work are highly relevant to public health because they employ neuroimaging methods to understand food decision-making. Findings from this study will inform health decision making and holds great potential for future translation across multiple health behaviors and scalable interventions to impact population health

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (2)

• Brain Activation in Self-Regulation Brain Regions

  Functional Magnetic Resonance Imaging will measure brain activation changes in self-regulation brain regions including the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex when participants view healthy compared to unhealthy food images before and after the guided imagery exercise

  1 hour

• Brain Activation in Reward Brain Regions

  Functional Magnetic Resonance Imaging will measure brain activation changes in reward brain regions including the ventromedial prefrontal cortex and striatum when participants view healthy compared to unhealthy food images before and after the guided imagery exercise

  1 hour

Secondary Outcomes (2)

• Food Choice

  1 hour

• Food Demand

  1 hour

Study Arms (1)

Guided Imagery

EXPERIMENTAL

Participants will listen to a guided imagery recording

Behavioral: Guided Imagery

Interventions

Guided Imagery BEHAVIORAL

The guided imagery exercise asks participants to think about positive associations with healthy foods and imagine their future healthy selves.

Guided Imagery

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• body mass index 25 to 55 kg/m2
• right-handed
• not currently dieting or attempting to lose weight.

You may not qualify if:

• serious medical illness unsuitable for the magnetic resonance imaging scanner based on best clinical judgment
• any neurologic or current psychiatric diagnosis
• currently taking anti-seizure medication
• history of concussion
• left-handedness
• risk for hazard due to magnetic fields such as metal in the body surgically or accidentally
• pregnancy

Sponsors & Collaborators

• University of Kansas Medical Center: lead

Study Sites (1)

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

MeSH Terms

Conditions

Overweight; Obesity

Interventions

Imagery, Psychotherapy

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Psychotherapy; Behavioral Disciplines and Activities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be assigned to a guided imagery exercise

Study Record Dates

• First Submitted: May 29, 2019
• First Posted: June 6, 2019
• Study Start: April 24, 2019
• Primary Completion: July 11, 2019
• Study Completion: July 11, 2019
• Last Updated: August 5, 2019

Record last verified: 2019-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Data will be available 1-year after study completion
• Access Criteria: Researchers may contact the Principal Investigator to request the data and will be required to sign research sharing agreements with the institution before gaining access.

Locations

US (1)