Peripheral Vascular Disease and Coronary Artery Disease
The Relationship Between Peripheral Artery Plaque Characteristics Evaluated by Ultrasound and Coronary Culprit Lesion Characteristics Evaluated by OCT in ACS Patients
1 other identifier
observational
350
1 country
1
Brief Summary
This study aims at evaluating the relationship between peripheral artery plaque characteristics evaluated by ultrasound and coronary culprit lesion characteristics evaluated by OCT in ACS patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 8, 2018
CompletedFirst Submitted
Initial submission to the registry
May 30, 2019
CompletedFirst Posted
Study publicly available on registry
June 3, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedSeptember 16, 2020
September 1, 2020
1.1 years
May 30, 2019
September 13, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Differences in ultrasound parameters of peripheral artery plaque according to different coronary culprit lesion morphology.
Plaque rupture is characterized by the presence of fibrous cap discontinuity with a cavity formation. plaque erosion is characterized by the presence of the attached thrombus overlying an intact and visual plaque, luminal surface irregularity at the culprit lesion in the absence of thrombus, or attenuation of the underlying plaque by thrombus without superficial lipid or calcification immediately proximal or distal to the site of thrombus.Patients with plaque erosion have less plaques, lower intima-media thickness (IMT), lower plaque score (PS) compared to patients with plaque rupture.
Baseline
Eligibility Criteria
ACS patients
You may qualify if:
- Diagnosed as ACS underwent coronary angiography and OCT examination
- Agreed to accept peripheral artery ultrasound examination
You may not qualify if:
- In-stent restenosis, coronary dissection, coronary spam, thrombus
- left main artery disease
- Age\>85 years old
- Cardiogenic shock or stroke admission
- Severe hepatic or renal dysfunction
- Poor quality of OCT image or massive thrombus
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The Second Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150081, China
Related Publications (1)
Weng Z, Zhao C, Qin Y, Liu C, Pan W, Hu S, He L, Xu Y, Zeng M, Feng X, Gao R, Yu X, Liu M, Yi B, Zhang D, Koniaeva E, Musin T, Mohammad D, Zhu B, Sun Y, Hou J, Tian J, Mintz GS, Jia H, Yu B. Peripheral atherosclerosis in acute coronary syndrome patients with plaque rupture vs plaque erosion: A prospective coronary optical coherence tomography and peripheral ultrasound study. Am Heart J. 2023 Sep;263:159-168. doi: 10.1016/j.ahj.2023.06.006. Epub 2023 Jun 14.
PMID: 37327980DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of Cardiology of The Seconf Affiliated Hospital of Harbin Mdical University
Study Record Dates
First Submitted
May 30, 2019
First Posted
June 3, 2019
Study Start
November 8, 2018
Primary Completion
December 31, 2019
Study Completion
December 31, 2019
Last Updated
September 16, 2020
Record last verified: 2020-09
Data Sharing
- IPD Sharing
- Will not share