Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study

NCT03965338 | Completed DMC

• 2 other identifiers: 4508.24.12.20184508 TSA-2019-4508
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Brain cortex controls movement but the influence of peripheral component of movement on the cortex is not known. Functional Magnetic Resonance Imaging(fMRI) studies in stroke and fantom limb patients investigate cortex areas activated during execution and imagination of complex hand movements. These studies aim to understand the mechanisms of the motor component of movement but the results are limited as there is no effector organ in fantom limb patients and the affecting organ is damaged in stroke patients. The investigators hypothesized that the areas of the cortex that is activated to remember, set-up and order to move can be isolated from the areas that are activated during the motor component of movement. To prove this hypothesis the investigators developed a model that investigate the brain activation areas during the patient try to execute and imagine doing a complex motor task (sequential opposition with the thumb to the other four fingers) with a peripherally blocked arm. Brain fMRI in 15 right-handed patients scheduled to undergo right-hand surgery with peripheral block anesthesia will be obtained before the surgery day and just before surgery after the block. Participants will be screened when executing the task (after the block they just attempt), during rest and during they imagine doing the task. Bilateral cortex activation areas will be compared when the right hand was intact and was peripherally blocked. There are many unknowns in the relationship between the brain-peripheric organ during movement. The investigators hope that some of these mechanisms will be identified by the new model we used in our study. The final benefit will be to develop stroke therapies and new therapies for neuropathic pain which is closely related to motor function.

Conditions

Regional Anaesthesia; Functional Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (2)

• Compare the area of brain activation during the participant try to perform a motor task when the hand is blocked with area of brain activation when the hand actually perform the task by using fMRI

  complex hand movement: sequential repetitive thumb to other four digit opposition with the right hand

  1 year

• Comparing brain activation areas while the participant imagine to perform a motor task when the hand is blocked with brain activation areas when the hand is intact, by fMRI

  complex hand movement: sequential repetitive thumb to other four digit opposition with the right hand

  1 year

Secondary Outcomes (1)

• Comparing the area of ipsilateral cortex brain activity when the participant is intending to perform the complex motor task with the area while imagining doing the complex motor task when the arm is blocked by anesthesia.

  1 year

Study Arms (1)

fMRI brain activity

screening

Diagnostic Test: fMRI

Interventions

fMRI DIAGNOSTIC_TEST

Screening

fMRI brain activity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled to have right-hand surgery with peripheral blockage of the arm

You may qualify if:

• \>18 years
• have right-hand surgery with peripheral blockage of the arm
• who give written informed consent

You may not qualify if:

• who do not give written informed consents,
• use their left hand dominantly,
• have a neurologic or psychiatric disease,
• have hearing and visual loss,
• have a history of substance abuse
• have surgery in the previous 12 months,
• have major systemic disease(ASA III and IV),
• have history of drugs that alter neurologic activity,
• are unable to stay at MR machine without sedation,
• with an expected surgery duration of more than 3 hours,
• have a motor deficit at their right hand that makes the performance of the motor task impossible

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

AkdenizU

Antalya, 07058, Turkey (Türkiye)

Location

Related Publications (3)

• Le Bihan D, Karni A. Applications of magnetic resonance imaging to the study of human brain function. Curr Opin Neurobiol. 1995 Apr;5(2):231-7. doi: 10.1016/0959-4388(95)80031-x.

  PMID: 7620312 BACKGROUND

• Ruffino C, Papaxanthis C, Lebon F. Neural plasticity during motor learning with motor imagery practice: Review and perspectives. Neuroscience. 2017 Jan 26;341:61-78. doi: 10.1016/j.neuroscience.2016.11.023. Epub 2016 Nov 25.

  PMID: 27890831 BACKGROUND

• Osumi M, Sumitani M, Wake N, Sano Y, Ichinose A, Kumagaya S, Kuniyoshi Y, Morioka S. Structured movement representations of a phantom limb associated with phantom limb pain. Neurosci Lett. 2015 Sep 25;605:7-11. doi: 10.1016/j.neulet.2015.08.009. Epub 2015 Aug 10.

  PMID: 26272300 BACKGROUND

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Utku A Senol, Prof.

  Akdeniz University Radiology Department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 20, 2019
• First Posted: May 29, 2019
• Study Start: January 1, 2019
• Primary Completion: January 12, 2020
• Study Completion: April 12, 2020
• Last Updated: February 6, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)