Physical Activity and Its Impact on Colon Cancer Surgery

NCT03947840 | Completed

• 1 other identifier: PACOS
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology. The hypothesis is that patients who are more physical active have less postoperative complications and different histological immunological response around the tumor. The investigators are testing the patients before the surgery with physical tests for fitness, strength and physical activity level. Questionnaires are also filled by the patients for pain, anxiety, depression and motivation for life style changes. Their body mass is analyzed with a DEXA (Dual-energy X-ray absorptiometry scan). For one years the investigators are monitoring their activity and follow up for physical tests, DEXA and questionnaires is at 6 and 12 months. The histology is analyzed after surgery to se if there is a different immunological response around the tumor.

Conditions

Colon Cancer; Physical Activity

Keywords

Colon cancer; Physical activity

Outcome Measures

Primary Outcomes (2)

• Number of postoperative complications

  To study if there are differences in postoperative complications in different active patients.

  1 year

• Rate of immunological response

  To study if there is a difference in immunological reaction among physical active patients.

  1 year

Secondary Outcomes (1)

• Rate of recovery in physical activity

  1 year

Interventions

Physical activity BEHAVIORAL

Se their physical activity level

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who are going to surgery due to colon cancer.

You may qualify if:

• years.
• Colon cancer which is going to surgery

You may not qualify if:

• Not able to do physical tests
• Severe disease that makes a risk to do tests.
• Not able to make informed consent due to psychic disease or dementia

Sponsors & Collaborators

• Umeå University: lead
• Västerbotten County Council, Sweden: collaborator

Study Sites (1)

Region Vasterbotten, centre of surgery

Umeå, Västerbotten County, 90185, Sweden

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Histological samples from the tumor

MeSH Terms

Conditions

Colonic Neoplasms; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Karin Strigård

  Umeå Universitet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2019
• First Posted: May 13, 2019
• Study Start: January 30, 2019
• Primary Completion: February 20, 2024
• Study Completion: February 20, 2024
• Last Updated: February 21, 2024

Record last verified: 2024-02

Locations

SE (1)