NCT03218605

Brief Summary

Previous studies have shown that a decreased blood flow is a risk factor in the occurrence of Achilles tendon (AT) injuries. Based on the current literature, no consensus was reached as to the most solid warming-up of the AT. Therefore, knowledge about activities which increase blood flow in the AT could be useful in the development of a solid warming-up programme for the AT. The aim of this investigation was to define the influence of different kinds of physical activity on the vascularisation of the AT in a healthy asymptomatic population. Subjects performed five activities in randomized order: running, static stretch, dynamic stretch, cycling and rope skipping. The vascularisation of the AT of the dominant limb was measured with the non-invasive oxygen-to-see (O2C) device. Blood flow was measured before, immediately after, five and ten minutes after activity to investigate the duration of the vascular response to activity.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2014

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2014

Completed
3.3 years until next milestone

First Submitted

Initial submission to the registry

July 5, 2017

Completed
9 days until next milestone

First Posted

Study publicly available on registry

July 14, 2017

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2018

Completed
Last Updated

December 1, 2021

Status Verified

November 1, 2021

Enrollment Period

3.8 years

First QC Date

July 5, 2017

Last Update Submit

November 30, 2021

Conditions

Keywords

Achilles tendonWarming-upVascularisationPhysical activityOxygen-to-See (O2C)

Outcome Measures

Primary Outcomes (1)

  • Change in Achilles tendon blood flow

    measured with the non-invasive O2C device

    3 minutes before and immediately (0 minutes) after the physical activity to assess the change in blood flow due to the physical activity

Study Arms (1)

healthy active participants

EXPERIMENTAL
Other: physical activity

Interventions

Subjects performed five activities: running, static stretch, dynamic stretch, cycling and rope skipping

healthy active participants

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • no history of Achilles tendon complaints
  • healthy and active adolescents

You may not qualify if:

  • history of Achilles tendon pain or current complaints
  • not healthy or not active population
  • children

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ghent University

Ghent, Belgium

Location

Related Publications (1)

  • Wezenbeek E, De Clercq D, Mahieu N, Willems T, Witvrouw E. Activity-Induced Increase in Achilles Tendon Blood Flow Is Age and Sex Dependent. Am J Sports Med. 2018 Sep;46(11):2678-2686. doi: 10.1177/0363546518786259. Epub 2018 Aug 1.

MeSH Terms

Conditions

Motor ActivityNeovascularization, Pathologic

Interventions

Exercise

Condition Hierarchy (Ancestors)

BehaviorMetaplasiaPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 5, 2017

First Posted

July 14, 2017

Study Start

March 1, 2014

Primary Completion

January 1, 2018

Study Completion

January 1, 2018

Last Updated

December 1, 2021

Record last verified: 2021-11

Locations