NCT03947762

Brief Summary

The purpose of the protocol is to estimate the progression-free survival (PFS) rate in subjects diagnosed with PanNET, according to investigator assessment, at 24 months after treatment initiation with lanreotide 120 mg every 28 days.

Trial Health

60
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
54

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2019

Geographic Reach
2 countries

46 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 10, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 13, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

July 3, 2019

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2021

Completed
Last Updated

June 14, 2021

Status Verified

June 1, 2021

Enrollment Period

1.8 years

First QC Date

May 10, 2019

Last Update Submit

June 9, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Progression-free survival (PFS) rate at 24 months

    To estimate the progression-free survival (PFS) rate in subjects diagnosed with PanNET, according to investigator assessment.

    24 months

Secondary Outcomes (10)

  • Progression-free survival (PFS) rate at 12 months

    12 months

  • Medical tumour-related intervention

    Baseline

  • Time from diagnosis to first therapeutic intervention

    Baseline

  • Quality of Life (QoL)

    From baseline up to 24 months

  • Median time to lanreotide discontinuation

    Up to 24 months

  • +5 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Hospital patients

You may qualify if:

  • Subjects aged ≥ 18
  • Subjects diagnosed of functioning or non-functioning PanNET, G1/ G2 (Ki67≤10%) unresectable locally advanced tumour or metastatic disease, who have been treated with lanreotide 120mg every 28 days for at least 3 months and a maximum of 12 months
  • Subject with Eastern Cooperative Oncology Group (ECOG) ≤2

You may not qualify if:

  • Subject who is participating in an interventional study
  • Pregnant or breast-feeding women
  • Subject who has received any previous therapy for PanNET (such as octreotide LAR, Molecular Targeted Therapy (MTT), Peptide receptor radionuclide therapy (PRRT), chemotherapy, etc.) except short-acting octreotide subcutaneous (SC) used for symptomatic control of functioning tumours

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (46)

IPO Coimbra

Coimbra, 300-075, Portugal

Location

IPO Lisboa

Lisbon, 1099-023, Portugal

Location

Hospital São João

Porto, 4200-319, Portugal

Location

Hospital General de Alicante

Alicante, 03010, Spain

Location

Hospital Torrecardenas

Almería, 04009, Spain

Location

Hospital Universitario de Badajoz

Badajoz, 06010, Spain

Location

ICO Badalona

Badalona, 08916, Spain

Location

Hospital de Cruces

Barakaldo, 48903, Spain

Location

Hospital Universitario Vall Hebrón

Barcelona, 08035, Spain

Location

Hospital Santa Creu I Sant Pau

Barcelona, Spain

Location

Hospital Basurto

Bilbao, 48013, Spain

Location

Hospital Universitario de Burgos

Burgos, 09006, Spain

Location

Hospital Universitario Puerto Real

Cadiz, 11510, Spain

Location

Hospital San Pedro de Alcántara

Cáceres, 10003, Spain

Location

Hospital General Ciudad Real

Ciudad Real, 13005, Spain

Location

Hospital Universitario Reina Sofia

Córdoba, 14004, Spain

Location

Hospital Donostia

Donostia / San Sebastian, 20014, Spain

Location

Hospital Virgen de las Nieves

Granada, 18014, Spain

Location

Hospital Juan Ramón Jimenez

Huelva, 21005, Spain

Location

Hospital Can Misses

Ibiza Town, 07800, Spain

Location

Hospital de Jerez

Jerez de la Frontera, 11407, Spain

Location

ICO Bellvitge

L'Hospitalet de Llobregat, 08908, Spain

Location

Hospital U. de Gran Canaria Negrín

Las Palmas de Gran Canaria, 35010, Spain

Location

Hospital Virgen de La Victoria

Málaga, 29010, Spain

Location

Hospital Clínico U. Virgen de la Arrixaca

Murcia, 30120, Spain

Location

Hospital Morales Meseguer

Murcia, Spain

Location

Hospital Santa María Nai

Ourense, 32005, Spain

Location

Hospital Universitario Central de Asturias

Oviedo, 33011, Spain

Location

Hospital Son Espases

Palma de Mallorca, 07120, Spain

Location

Hospital de Navarra

Pamplona, 31008, Spain

Location

Hospital Sant Joan de Reus

Reus, 43204, Spain

Location

Corporació Sanitària Parc Taulí

Sabadell, Spain

Location

Hospital Clínico de Salamanca

Salamanca, 37007, Spain

Location

Hospital U. Nuestra Señora de Candelaria

Santa Cruz de Tenerife, 38010, Spain

Location

Hospital Marqués de Valdecillas

Santander, 39008, Spain

Location

Hospital Conxo

Santiago de Compostela, 15706, Spain

Location

Hospital General de Segovia

Segovia, 40002, Spain

Location

Hospital Virgen Macarena

Seville, 41009, Spain

Location

Hs. Virgen del Rocio

Seville, 41013, Spain

Location

Hospital Mutua Terrassa

Terrassa, 08221, Spain

Location

Hospital Virgen de la Salud Toledo

Toledo, 45004, Spain

Location

Hospital General de Valencia

Valencia, 46014, Spain

Location

Hospital Universitario y Politécnico La Fe

Valencia, 46014, Spain

Location

Hospital Álvaro Cunqueiro

Vigo, 36312, Spain

Location

Hospital Lozano Blesa

Zaragoza, 50009, Spain

Location

Hospital Miguel Servet

Zaragoza, 50009, Spain

Location

MeSH Terms

Conditions

Adenoma, Islet Cell

Condition Hierarchy (Ancestors)

AdenomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsPancreatic NeoplasmsDigestive System NeoplasmsNeoplasms by SiteEndocrine Gland NeoplasmsDigestive System DiseasesPancreatic DiseasesEndocrine System Diseases

Study Officials

  • Ipsen Medical Director

    Ipsen

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 10, 2019

First Posted

May 13, 2019

Study Start

July 3, 2019

Primary Completion

April 30, 2021

Study Completion

April 30, 2021

Last Updated

June 14, 2021

Record last verified: 2021-06

Locations