Cognitive Decline in AD

NCT03946930 | Recruiting

• 1 other identifier: 2018.274
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

There is lack of information on the risk factors of accelerated cognitive decline in older people with Alzheimer disease (AD). The extent of neurodegeneration and white matter disease has been reported to be important factors. In addition there may be biomarkers e.g. inflammatory cytokines that can contribute to cognitive decline. The impact of care arrangement and physical activity may also be important. Insulin signaling is impaired in Alzheimer disease (AD). We therefore propose to perform a cohort study of older people with AD. This will be based on an on-going AD registry which was designed to identify genetic biomarkers for AD. Detailed neurocognitive tests and lifestyle information are available. In addition, volumetric MRI brain scans were performed in all AD subjects. The hypothesis is that MRI brain volumes, serum biomarkers, physical activity, physical functioning are independently associated with cognitive decline in older people with AD. The objective is to identify risk factors of accelerated cognitive decline so that preventive measures can be designed to delay dependency in AD.

Conditions

Alzheimer Disease

Outcome Measures

Primary Outcomes (1)

• Alzheimer's Disease Assessment Scale-cognitive subscale ADAS-COG

  Cognitive assessment for dementia

  24-Months

Eligibility Criteria

• Age: 65 Years - 92 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects are recruited from the geriatric outpatient clinics or memory clinic.

You may qualify if:

• Sufficient Cantonese competency for cognitive test
• Clinical diagnosis of AD
• FAST test staging 3-5

You may not qualify if:

• Subjects who refuse blood taking procedure
• No reliable family caregiver informant (person contact at least once a month)

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Timothy Kwok, MD

CONTACT

+852 35053145; tkwok@cuhk.edu.hk

Hazel Mok, BSc

CONTACT

+852 35053990; hazelmok@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 8, 2019
• First Posted: May 13, 2019
• Study Start: December 13, 2018
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: August 21, 2024

Record last verified: 2024-08

Locations

HK (1)