Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome

NCT03946189 | Completed

• 1 other identifier: BIO-2018-0033
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end expiratory pressure (PEEP), inspiratory time to expiratory time ratio (Ti:Te), and the peak alveolar pressure (Palv). The aim is to identify a new oxygenation index for stratification of severity of ARDS

Conditions

Acute Respiratory Distress Syndrome

Outcome Measures

Primary Outcomes (1)

• New oxygenation index

  Oxygenation index that incorporates ventilator parameters

  Immediate

Study Arms (3)

P/F less than 100

Patients receiving mechanical ventilation with paO2/FiO2 less than 100

Diagnostic Test: Obtaining arterial blood gases

P/F between 100 and 200

Patients receiving mechanical ventilation with paO2/FiO2 between 100 and 200

Diagnostic Test: Obtaining arterial blood gases

P/F between 200-300

Patients receiving mechanical ventilation with paO2/FiO2 between 200 and 300

Diagnostic Test: Obtaining arterial blood gases

Interventions

Obtaining arterial blood gases DIAGNOSTIC_TEST

Obtaining arterial blood sample

Also known as: No other intervention

P/F between 100 and 200; P/F between 200-300; P/F less than 100

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of both gender and greater than 18 years old receiving mechanical ventilation in the ICU

You may qualify if:

• Patients receiving mechanical ventilation in the Intensive Care Unit.
• Patients in whom the managing medical team requested an arterial blood gas (ABG) analysis.

You may not qualify if:

• Patients in whom arterial blood gas could not be obtained or not ordered.

Sponsors & Collaborators

• American University of Beirut Medical Center: lead

Study Sites (1)

American University of Beirut

Beirut, Lebanon

Location

Related Publications (1)

• El-Khatib MF, Bouakl IJ, Ayoub CM, Chatburn RL, Farhat H, Msheik M, Fakih MH, Hallal AH. Comparison of the Oxygenation Factor and the Oxygenation Ratio in Subjects With ARDS. Respir Care. 2020 Dec;65(12):1874-1882. doi: 10.4187/respcare.07669. Epub 2020 Jul 21.

  PMID: 32694182 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2019
• First Posted: May 10, 2019
• Study Start: March 14, 2018
• Primary Completion: May 1, 2019
• Study Completion: May 1, 2019
• Last Updated: May 10, 2019

Record last verified: 2019-05

Locations

LE (1)