Cognitive and Motor Benefits of Standing

NCT03944564 | Unknown DMC

• 1 other identifier: KOGIS
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Upright-working has been proven to benefit health by combating the negative effects of physical inactivity. However, long-term commitment to static standing regimens may be limited due to symptoms of musculoskeletal fatigue that may develop during prolonged static standing in the absence of facilitated weight shifting. We propose a dynamic standing approach (working while standing accompanied by small periodic stepping movements) as a more tolerable and thereby more applicative lifestyle modification.

Conditions

Pain, Acute; Muscle Tone Abnormalities; Work-Related Condition; Sensory Deficit

Keywords

cognition; brain activity; cognitive reserve; work productivity; musculoskeletal discomfort; attention

Outcome Measures

Primary Outcomes (3)

• Overall movement - accelerometry

  Overall movement (counts/min)

  change in activity levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

• Musculoskeletal discomfort

  Rate of total musculoskeletal discomfort development (mm/min)

  change in musculoskeletal discomfort levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

• Leg swelling

  Average swelling for both legs (cm)

  change in leg swelling levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

Secondary Outcomes (4)

• Oxygen uptake

  change in oxygen consumption between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

• Attention levels

  change in attentional levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

• Executive control

  change in executive control and cognitive switching levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

• Brain electrocortical activity

  change in electrocortical activity levels between all three conditions, which will be measured on average 3 days in-between (maximum length of measurements per subject = 15 days)

Study Arms (3)

Condition 1: sitting

ACTIVE COMPARATOR

Four hours of sitting condition will be applied with ad-libitum breaks for toilet use and stretching. During this condition all cognitive, motor and pain scales will be monitored.

Behavioral: Sitting

Condition 2: static standing

ACTIVE COMPARATOR

Four hours of static standing condition will be applied with ad-libitum breaks for toilet use and stretching. During this condition all cognitive, motor and pain scales will be monitored.

Behavioral: Static standing

Condition 3: dynamic standing

ACTIVE COMPARATOR

Four hours of static standing condition will be applied with ad-libitum breaks for toilet use and stretching. During this condition all cognitive, motor and pain scales will be monitored.

Behavioral: Dynamic standing

Interventions

Sitting BEHAVIORAL

We propose a dynamic standing approach (working while standing accompanied by small periodic stepping movements) as a more tolerable and thereby more applicative lifestyle modification. To evaluate this form on healthy subjects, three different conditions will be applied: 4 hours of sitting, static standing and dynamic standing. Both standing conditions will be done with height-adjustable table which was developed at the University of Michigan (Ann Arbor, Michigan, USA)

Also known as: SIT

Condition 1: sitting

Static standing BEHAVIORAL

We propose a dynamic standing approach (working while standing accompanied by small periodic stepping movements) as a more tolerable and thereby more applicative lifestyle modification. To evaluate this form on healthy subjects, three different conditions will be applied: 4 hours of sitting, static standing and dynamic standing. Both standing conditions will be done with height-adjustable table which was developed at the University of Michigan (Ann Arbor, Michigan, USA)

Also known as: STAT

Condition 2: static standing

Dynamic standing BEHAVIORAL

We propose a dynamic standing approach (working while standing accompanied by small periodic stepping movements) as a more tolerable and thereby more applicative lifestyle modification. To evaluate this form on healthy subjects, three different conditions will be applied: 4 hours of sitting, static standing and dynamic standing. Both standing conditions will be done with height-adjustable table which was developed at the University of Michigan (Ann Arbor, Michigan, USA)

Also known as: DYN

Condition 3: dynamic standing

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \. Healthy adults (both gender, age range 18-64 years) who are currently employed.

You may not qualify if:

• Inability to stand or walk without an assistive device
• History of symptoms in stance that preclude safe and comfortable participation, such as dizziness and lightheadedness, orthostasis, severe symptomatic leg or back musculoskeletal pain, or medication side effects
• History of symptomatic cardiovascular or pulmonary disease
• History of rheumatic arthritis
• History of stroke or other neurologic conditions with residual sensorimotor deficits
• History of chronic pain syndrome requiring narcotic analgesics
• Neurological disorders
• Evidence of dementia
• Diabetics: low or poorly controlled blood glucose
• Any other history of medical or psychiatric comorbidity precluding safe participation in the project

Sponsors & Collaborators

• Science and Research Centre Koper: lead
• University of Michigan: collaborator

Study Sites (1)

Science and research centre Koper

Koper, 6000, Slovenia

RECRUITING

Related Publications (6)

• Levine JA, Schleusner SJ, Jensen MD. Energy expenditure of nonexercise activity. Am J Clin Nutr. 2000 Dec;72(6):1451-4. doi: 10.1093/ajcn/72.6.1451.

  PMID: 11101470 BACKGROUND

• Levine JA, Kotz CM. NEAT--non-exercise activity thermogenesis--egocentric & geocentric environmental factors vs. biological regulation. Acta Physiol Scand. 2005 Aug;184(4):309-18. doi: 10.1111/j.1365-201X.2005.01467.x.

  PMID: 16026422 BACKGROUND

• Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes. 2007 Nov;56(11):2655-67. doi: 10.2337/db07-0882. Epub 2007 Sep 7.

  PMID: 17827399 BACKGROUND

• Chau JY, van der Ploeg HP, Dunn S, Kurko J, Bauman AE. A tool for measuring workers' sitting time by domain: the Workforce Sitting Questionnaire. Br J Sports Med. 2011 Dec;45(15):1216-22. doi: 10.1136/bjsports-2011-090214. Epub 2011 Sep 22.

  PMID: 21947817 BACKGROUND

• Cook AJ, Degood DE. The cognitive risk profile for pain: development of a self-report inventory for identifying beliefs and attitudes that interfere with pain management. Clin J Pain. 2006 May;22(4):332-45. doi: 10.1097/01.ajp.0000209801.78043.91.

  PMID: 16691085 BACKGROUND

• Waddell G, Newton M, Henderson I, Somerville D, Main CJ. A Fear-Avoidance Beliefs Questionnaire (FABQ) and the role of fear-avoidance beliefs in chronic low back pain and disability. Pain. 1993 Feb;52(2):157-168. doi: 10.1016/0304-3959(93)90127-B.

  PMID: 8455963 BACKGROUND

MeSH Terms

Conditions

Acute Pain

Interventions

Sitting Position

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Posture; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Uros Marusic, PhD

CONTACT

041529226; uros.marusic@zrs-kp.si

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Participants will receive a general information about the study protocol and received three conditions in a random order.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, controlled crossover trial

Study Record Dates

• First Submitted: May 6, 2019
• First Posted: May 9, 2019
• Study Start: September 10, 2019
• Primary Completion: September 1, 2022
• Study Completion: September 1, 2022
• Last Updated: April 22, 2021

Record last verified: 2021-04

Locations

SL (1)