Correlation Between Changes in End-Tidal Carbon Dioxide and Stroke Volume Variation Detected by Electrical Cardiometry as A Predictor of Fluid Volume Responsiveness in Hemodynamically Unstable Patients in the Intensive Care

NCT03932617 | Completed FDA Device

• 1 other identifier: 32880/01/19
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will be conducted to assess the role of end-tidal carbon dioxide (PETCO2) monitoring to predict the fluid volume responsiveness in correlation with stroke volume variation detected by electrical cardiometry in patients with hemodynamic instability.

Conditions

End Tidal Carbon Dioxide; Cardiometry; Fluid Responsiveness; Shock

Outcome Measures

Primary Outcomes (1)

• Assessment of sensitivity and specificity of end tidal carbon dioxide monitoring in predicting fluid responsiveness in correlation with stoke volume variation detected by cardiometry

  24 hour

Study Arms (2)

fluid responders

Device: end tidal carbon dioxide by capnography

fluid non responders

Device: end tidal carbon dioxide by capnography

Interventions

end tidal carbon dioxide by capnography DEVICE

Moreover, since PETCO2 is mainly determined by tissue CO2 production (VCO2), alveolar ventilation and CO, when stable metabolic conditions are assumed and minute ventilation is kept constant, acute changes in PETCO2 have been shown to correlate strongly with changes in CO. Thus, PETCO2 has been suggested as a simple economic and noninvasive alternative for continuous assessment of CO in different shock states.

fluid non responders; fluid responders

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Tanta University Hospital at surgical intensive care unit (SICU).

You may qualify if:

• Patients who will be 18 years or older.
• Patients on mechanical ventilation in the intensive care.
• Patients developing hypotension (MABP) \<65 mmHg.

You may not qualify if:

• Patients with organ/s failure at presentation.
• Patients with deep venous thrombosis.
• Patients with limb and pelvic fractures.
• Pregnant patients

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University Hospitals

Tanta, ElGharbiaa, Egypt

Location

MeSH Terms

Conditions

Shock

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: April 28, 2019
• First Posted: May 1, 2019
• Study Start: June 1, 2019
• Primary Completion: January 1, 2021
• Study Completion: January 31, 2021
• Last Updated: February 21, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

EG (1)