NCT03924583

Brief Summary

Catheter-related thrombosis (CRT) has been found as the major complication of the established central venous catheter in intensive care unit (ICU) patients. Its reported incidence varies from 5 to 66 %. Although most cases are asymptomatic, in up to 10 - 15 % of the patients pulmonary embolism occurs. In addition, CRT is associated with the risk of infection, post-thrombotic syndrome and with general disruption of the management of the underlying disease. The most accessible diagnostic method for CRT recognition is duplex ultrasonography. However, screening of CRT by duplex ultrasonography is not common approach in ICUs. Normally, duplex ultrasonography is performed by physicians. In this setting, implementation of the screening in ICU would be time consuming and practically unrealizable. Delegating this competence to ICU nurses can increase availability of this screening method. Therefore, as a first step, investigators decided to perform a validation clinical study to verify the diagnostic accuracy of duplex ultrasonography of the venous system for CRT screening performed by a general nurse.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
150

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Mar 2019

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 18, 2019

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

April 17, 2019

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 23, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 18, 2019

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2020

Completed
Last Updated

April 23, 2019

Status Verified

April 1, 2019

Enrollment Period

6 months

First QC Date

April 17, 2019

Last Update Submit

April 20, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence of catheter related thrombosis - physician and nurse

    Diagnostic reliability of duplex ultrasonography examination of the venous system for screening of catheter-related thrombosis performed by a general nurse

    24hours

Interventions

Duplex ultrasonographyDIAGNOSTIC_TEST

Ultrasound examination of whole vena cava venous system with central venous catheter inserted, using duplex US method to detect catheter related thrombosis

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patient hospitalized in ICU, with central venous catheter inserted for more than 48 hours

You may qualify if:

  • central venous catheter more than 48 hours in situ
  • consent of a patient

You may not qualify if:

  • technical difficulties of ultrasound machine
  • unfavorable local findings - inflammation of skin, excoriation etc.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Clinic of anaesthesiology, resuscitaion and perioperative care, Masaryk Hospital,

Ústí nad Labem, 40113, Czechia

RECRUITING

MeSH Terms

Interventions

Ultrasonography, Doppler, Duplex

Intervention Hierarchy (Ancestors)

Ultrasonography, DopplerUltrasonographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Officials

  • Barbora Pakostová, M.D.

    Krajská zdravotní a.s., Masaryk Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Barbora Pakostová, M.D.

CONTACT

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Medical doctor

Study Record Dates

First Submitted

April 17, 2019

First Posted

April 23, 2019

Study Start

March 18, 2019

Primary Completion

September 18, 2019

Study Completion

September 30, 2020

Last Updated

April 23, 2019

Record last verified: 2019-04

Locations