The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction

NCT03915808 | Completed DMC

• 1 other identifier: 20190201
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This is a double-blinded randomized controlled trial, to evaluate the effectiveness of daily supplementation of 3.2 g CLA on body fat reduction and lipid profile in overweight or obese Chinese adults, during a lifestyle counselling-based weight loss.

Conditions

Obesity; Adiposity

Outcome Measures

Primary Outcomes (1)

• Change of body fat percentage

  week 0 and week 12

Secondary Outcomes (9)

• Change of body fat mass

  week 0 and week 12

• Change of body mass index

  week 0 and week 12

• Change of weight

  week 0, week 4, week 8, and week 12

• Change of waist circumference

  week 0 and week 12

• Change of triglycerides

  week 0 and week 12

Study Arms (2)

Conjugated linoleic acid plus lifestyle counselling

EXPERIMENTAL

supplementation of 3.2 g/day conjugated linoleic acid and receive education sessions regularly

Dietary Supplement: Conjugated linoleic acid group

Sunflower oil plus lifestyle counselling

PLACEBO COMPARATOR

supplementation of equivalent sunflower oil, and receive education sessions regularly

Dietary Supplement: Sunflower oil group

Interventions

Conjugated linoleic acid group DIETARY_SUPPLEMENT

supplementation of 3.2 g/day conjugated linoleic acid in 8 capsules, and receive education sessions every four weeks (Dietary and lifestyle counselling, featured with low fat and low added sugar, moderate physical activity)

Conjugated linoleic acid plus lifestyle counselling

Sunflower oil group DIETARY_SUPPLEMENT

supplementation of equivalent sunflower oil in 8 capsules, and receive education sessions every four weeks (Dietary and lifestyle counselling, featured with low fat and low added sugar, moderate physical activity)

Sunflower oil plus lifestyle counselling

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• \) Body fat percentage ≥ 20% for men, Body fat percentage ≥ 30% for women ; 2) aged from 18 to 45 years old.

You may not qualify if:

• Pregnancy or lactation;
• Abnormal liver or kidney function indicated by physical examination within 6 months;
• Gastrointestinal problems that affect the complying with the procedure;
• Sever cardiovascular disease;
• Active cancer;
• Mental diseases, epilepsy or using anti-depression drugs;
• Using medicine that affect body weight;
• Participating in other scientific studies within 3 months before the study.

Sponsors & Collaborators

• Jiaomei Yang: lead

Study Sites (1)

Xi'an Jiaotong University Health Science Center

Xi'an, Shaanxi, 710061, China

Location

Related Publications (3)

• Jia K, She Y, He Y, He J, He Y, Xu K, Ma G, Li W, He C, Feng X, Wang M, Tang A, Sun X, Kong L, Liu X. Conjugated Linoleic Acid Supplementation Suppresses the De Novo Lipogenesis in Adults With High Body Fat: A Double-Blind, Randomized, Placebo-Controlled Trial. Mol Nutr Food Res. 2025 Dec;69(24):e70306. doi: 10.1002/mnfr.70306. Epub 2025 Oct 30.

  PMID: 41169023 DERIVED

• He Y, Xu K, Li Y, Chang H, Liao X, Yu H, Tian T, Li C, Shen Y, Wu Q, Liu X, Shi L. Metabolomic Changes Upon Conjugated Linoleic Acid Supplementation and Predictions of Body Composition Responsiveness. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2606-2615. doi: 10.1210/clinem/dgac367.

  PMID: 35704027 DERIVED

• Chang H, Gan W, Liao X, Wei J, Lu M, Chen H, Wang S, Ma Y, Wu Q, Yu Y, Liu X. Conjugated linoleic acid supplements preserve muscle in high-body-fat adults: A double-blind, randomized, placebo trial. Nutr Metab Cardiovasc Dis. 2020 Sep 24;30(10):1777-1784. doi: 10.1016/j.numecd.2020.05.029. Epub 2020 Jun 8.

  PMID: 32684362 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Xin Liu, PhD

  Xi'an Jiaotong University Health Science Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Research Fellow

Model Details: This will be a parallel randomized, double-blinded, placebo-controlled trial. Sixty-six overweight or obese men and women aged from 18 to 50 years with elevated body fat percentage, who also meet our inclusion and exclusion criteria, will be randomly assigned to: the treatment group, daily supplementation of 3.2 g CLA (Cis-9, trans-11 isomers and trans-10, cis-12 isomers) plus lifestyle counselling weight loss program; or the control group, daily supplementation of sunflower oil. The intervention will include a 3-day run-in phase and 12-week interventional phase. At baseline and the end of the intervention, physical examination including questionnaires, anthropometric measurement, body composition by Dual Energy X-ray Absorptiometry (DXA), biological sample collection will be undertaken. During the invention, regular lifestyle counselling sessions will be delivered, and detailed record will be tracked for all participants to monitor and improve the adherence and safety.

Study Record Dates

• First Submitted: April 9, 2019
• First Posted: April 16, 2019
• Study Start: March 27, 2019
• Primary Completion: June 21, 2019
• Study Completion: July 21, 2019
• Last Updated: February 28, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)