Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy

NCT03915730 | Completed

• 1 other identifier: 2016/026
• Study Type: interventional
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and gingival index (GI), were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th-8th weeks. GCF PGRP-1 levels were analyzed by enzyme-linked immunosorbent assay.

Conditions

Smoking, Cigarette

Keywords

Chronic periodontitis; gingival crevicular fluid; initial periodontal therapy; peptidoglycan recognition proteins; smoking

Outcome Measures

Primary Outcomes (1)

• Change in peptidoglycan recognition protein-1

  Total amount of Peptidoglycan Recognition Protein-1 (µg) in gingival crevicular fluid

  Baseline and 3 months

Secondary Outcomes (1)

• Change in periodontal clinical parameter

  Baseline and 3 months

Study Arms (4)

Smokers with chronic periodontitis

EXPERIMENTAL

Patients who had teeth with 30% periodontal bone loss, presence of at least two nonadjacent sites per quadrant with probing pocket depths of ≥5 mm, and bleeding on probing were assigned as chronic periodontitis group Patients who have smoked for at least 10 years and a minimum of 10 cigarettes per day were assigned as current smokers.

Other: Initial periodontal therapy

Non-smokers with chronic periodontitis

EXPERIMENTAL

Patients who had teeth with 30% periodontal bone loss, presence of at least two nonadjacent sites per quadrant with probing pocket depths of ≥5 mm, and bleeding on probing were assigned as chronic periodontitis group Never smoked patients were included into the nonsmoker group

Other: Initial periodontal therapy

Smokers with periodontal healthy

NO INTERVENTION

Individuals were diagnosed periodontally healthy as without attachment loss, periodontal disease history, whole mouth bleeding scores of \<10% and a probing depth of ≤3 mm Patients who have smoked for at least 10 years and a minimum of 10 cigarettes per day were assigned as current smokers.

Non-smokers with periodontal healthy

NO INTERVENTION

Individuals were diagnosed periodontally healthy as without attachment loss, periodontal disease history, whole mouth bleeding scores of \<10% and a probing depth of ≤3 mm Never smoked patients were included into the nonsmoker group

Interventions

Initial periodontal therapy OTHER

Scaling and root planing and polishing with specific curettes were performed to patients with CP and oral hygiene education was provided to each patient.

Non-smokers with chronic periodontitis; Smokers with chronic periodontitis

Eligibility Criteria

• Age: 22 Years - 56 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Clinical diagnosis of severe chronic periodontitis
• Clinical diagnosis of periodontal health

You may not qualify if:

• have any systemic disease,
• to be alcohol consumer,
• to receive any periodontal therapy in the past 6 months,
• to take any drugs regularly
• to be pregnant and/or lactate.

Sponsors & Collaborators

• Kırıkkale University: lead

MeSH Terms

Conditions

Cigarette Smoking; Chronic Periodontitis; Smoking

Condition Hierarchy (Ancestors)

Tobacco Smoking; Behavior; Tobacco Use; Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 11, 2019
• First Posted: April 16, 2019
• Study Start: August 1, 2016
• Primary Completion: July 1, 2017
• Study Completion: November 1, 2017
• Last Updated: April 16, 2019

Record last verified: 2019-04