Behavioral Adaptation to Negative Social Cues in Depressed Patients According to Personal History of Suicide Attempt- COMPASS

NCT03898648 | Terminated

• 1 other identifier: RECHMPL19_0024
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Social interactions are part of daily life. To decide to interact with someone or not is a routine for humans. To ensure the quality of interpersonal relationships, emotional cues must be taken into account to adapt optimally the investigator's behavior. Difficulties in interpersonal relationships often trigger suicidal behavior. Suicide attempters are characterized by an impaired decision - making associated with difficulties in familial relationships. To date, little data on emotional recognition and social decision- making in clinical population is available. The study aims to compare behavioral response to negative social cues in 82 depressed patients according to their history of suicide attempt using a computerized neuropsychological task.

Conditions

Depression; History of Suicide Attempt

Keywords

Depression; Suicide attempt; Neuropsychology; Decision- making; Social interaction; Implicit Emotional processing

Outcome Measures

Primary Outcomes (1)

• Motivation to avoid anger during the emotional task

  Calculation of the proportion of avoidance vs. approach choices from people expressing anger

  At inclusion

Secondary Outcomes (4)

• Change in the proportion of avoidant choices in reverse trials compared to normal trials

  At inclusion

• Reaction time before clicking

  At inclusion

• Reaction time between first and second choices in reverse tests

  At inclusion

• Iowa Gambling Test score

  At inclusion

Study Arms (2)

Depressed patients with history of suicide attempt

EXPERIMENTAL

Depressed patients with a lifetime history of suicide attempt will be evaluated regarding their behavioral adaptation toward negative social cues.

Other: Waiting room task

Depressed patients without any history of suicide attempt

EXPERIMENTAL

Depressed patients without history of suicide attempt will be evaluated regarding their behavioral adaptation toward negative social cues.

Other: Waiting room task

Interventions

Waiting room task OTHER

The waiting room task consists in a computerized neuropsychological task in which the participant is asked to freely choose a chair to sit in a waiting room. In a row of four chairs, the two in the middle are occupied by two males or females. One of the two subjects sitting either has a neutral face, or express a negative emotion (fear or anger). To make their decision, participants must press the "S" keyboard button to go left or the "L" keyboard button to go right in a time limit of 1500 milliseconds. One third of the time, the cursor moves in the opposite direction to that requested by the participant. For example, if the subject presses "S", the cursor moves to the right instead of to the left. Those reverse trials are used to evaluate their motivation to correct the movement of the cursor. The participant will repeat the task 360 times for the assessment to be completed.

Depressed patients with history of suicide attempt; Depressed patients without any history of suicide attempt

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being between 18 and 65 years old
• Meeting the DSM-5 criteria for a current major depressive disorder
• For suicidal patients : having a lifetime history of suicide attempt
• For affective controls : having no personal history of suicide attempt
• Being able to understand the nature, purpose and methodology of the study
• Having signed the informed consent
• Being affiliated to a social security system

You may not qualify if:

• Current depressive episode with psychotic characteristics
• Mental retardation or sever medical co-morbidity
• Lifetime Diagnosis of schizophrenia or schizoaffective disorder
• Current manic or hypomanic episode
• Sensory or cognitive disability
• Pregnant or breastfeeding woman
• Deprivation of liberty (by judicial or administrative decision)
• Protection by law (guardianship or curatorship)
• Inability to understand, speak and write French

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• INSERM U960 - Cognitive Neuroscience Laboratory - Paris, France: collaborator

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Depression; Suicide, Attempted

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Suicide; Self-Injurious Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2019
• First Posted: April 2, 2019
• Study Start: April 9, 2019
• Primary Completion: April 10, 2021
• Study Completion: October 10, 2021
• Last Updated: January 5, 2022

Record last verified: 2021-12

Locations

FR (1)