Exercise Capacity in COPD
Reduced Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease -Relevance of Cardiovascular Comorbidities
1 other identifier
observational
100
1 country
1
Brief Summary
In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2019
CompletedFirst Submitted
Initial submission to the registry
March 11, 2019
CompletedFirst Posted
Study publicly available on registry
March 26, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedFebruary 11, 2020
February 1, 2020
1.8 years
March 11, 2019
February 10, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
Baseline
Secondary Outcomes (8)
measurement of dyspnoea quantified by the COPD assessment test as well as the modified Medical Research Council Scale
Baseline
Measurement of FEV1
Baseline
Measurement the capillary pO2 in mmHg and capillary pCO2 at baseline
Baseline
N-terminal pro brain natriuretic peptid (NTproBNP) in ng/L from peripheral venous blood at baseline
Baseline
Measurement of Maximum wattage during cardiopulmonary exercise testing
Baseline
- +3 more secondary outcomes
Study Arms (1)
patients with stable COPD
Interventions
Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing
Eligibility Criteria
Patients with stabile chronic obstructive pulmonary disease
You may qualify if:
- patients with stable chronic obstructive pulmonary disease, exacerbated or stable
- years
- sinus rhythm
- informed written consent
You may not qualify if:
- Inability to give written consent
- acute myocardial infarction with ST-segment elevations in last 30 days
- severe acute or chronic renal dysfunction
- severe heart failure-
- atrial fibrillation
- severe valve disease
- severe hypoxemia
- long term oxygen therapy or non invasive ventilation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Düsseldorf, Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, 40225, Germany
Biospecimen
Collection of 20 ml of peripheral blood Clinical routine such as NTproBNP, renal function, thyroid function, blood count
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Principle Investigator
Study Record Dates
First Submitted
March 11, 2019
First Posted
March 26, 2019
Study Start
March 1, 2019
Primary Completion
December 1, 2020
Study Completion
December 1, 2020
Last Updated
February 11, 2020
Record last verified: 2020-02