A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic Sclerosis

NCT03889509 | Completed

• 1 other identifier: YJJEP0001
• Study Type: observational
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

This protocol is of a systematic review for risk factors of pulmonary arterial hypertension in systemic sclerosis.

Conditions

Pulmonary Arterial Hypertension; Systemic Sclerosis

Keywords

systemic sclerosis; scleroderma; pulmonary hypertension; pulmonary arterial hypertension

Outcome Measures

Primary Outcomes (2)

• Prevalence of Pulmonary arterial hypertension in scleroderma

  to determine the prevalence associated with pulmonary arterial hypertension in scleroderma

  2 years from study start date

• Risk factors for pulmonary arterial hypertension in scleroderma

  to determine the risk factors associated with pulmonary arterial hypertension in scleroderma

  2 years from study start date

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study reflects a search strategy of available literature on pulmonary arterial hypertension in scleroderma.

You may qualify if:

• Studies were included they were (1) in patients with SSc; and if they (2) determined PAH with right heart catheterization; (3) involved a comparison of SSc patients with and without PAH; and (4) had sample size larger than 20.

You may not qualify if:

• Studies were excluded if they were review articles, and if the study was written in languages other than English. When the same patients were used in more than one analysis, the most recent or largest sample-size study was included.

Sponsors & Collaborators

• London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's: lead

Study Sites (1)

Rheumatology Clinic, St. Joseph's Health Care

London, Ontario, N6A 4V2, Canada

Location

MeSH Terms

Conditions

Pulmonary Arterial Hypertension; Scleroderma, Systemic; Scleroderma, Diffuse; Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Skin Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Janet E Pope, MD MPH

  St. Joseph's healthcare London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: March 22, 2019
• First Posted: March 26, 2019
• Study Start: March 1, 2018
• Primary Completion: March 1, 2020
• Study Completion: March 1, 2021
• Last Updated: August 19, 2022

Record last verified: 2022-08

Locations

CA (1)