Comparison to Psychological, Medical and Emotional Influencing Communication and Achievement Factors to Oncogenetics Tests

NCT03889171 | Completed

• 1 other identifier: 8893
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the study was to analyze the psychological and emotional determinants of domestic dissemination of information about genetic risk of cancer and to compare the level of diffusion syndromes in breast/ ovarian cancer ( BRCA1 / BRCA2) and colon/endometrial ( HNPCC )

Conditions

Cancer; Colorectal Cancer; Breast Cancer; Ovarian Cancer

Keywords

genetic testing; genes BRCA1; genes BRCA2; mutation; family; disclosure; psychology; DNA mismatch repair; genetic predisposition to disease; cancer; oncology

Outcome Measures

Primary Outcomes (2)

• intrafamilial disclosure rate

  The intrafamilial disclosure rate assessed the number of relatives informed by the proband about the mutation (according to the proband) out of the number of relatives at risk of carrying the familial mutation. Relatives who were considered "at risk" were first, second, third or fourth-degree relatives, older than 18 years and related to the relevant side of the family or, if unknown, just related to the proband whatever the family side.

  On average 1 year

• relatives' genetic targeted testing uptake rate

  The relatives' genetic targeted testing uptake rate assessed the number of relatives considered by the proband to have taken up the genetic targeted testing out of the number of relatives informed by the proband. To assess the potential bias of the proband's perception of genetic targeted testing uptake by relatives, we compared the number of relatives who underwent genetic targeted testing according to the proband with the number of tests actually performed. This anonymous comparison was performed in a subset of the population within the geographic regional area of Montpellier where all analyses are centralized in a single laboratory. Probands were asked how many relatives living in the region underwent genetic testing and this number was compared with the information available from the University Laboratory of Montpellier.

  On average 1 year

Interventions

Behaviour BEHAVIORAL

Comparison to psychological, medical and emotional Influencing communication and achievement factors to Oncogenetics tests

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

female and male participants are being studied

You may qualify if:

• Patient having a deleterious genetic mutation on genes BRCA1 and/or BRCA2 and or on genes MMR
• The patient being of the family (who carried out a full analysis of BRCA1/BRCA2 and/or those MMR )

You may not qualify if:

• Patient not carrying a deleterious genetic mutation on the BRCA1/2 genes and/or those of the MMR system,
• Patient under guardianship, curator or unable to give his non-opposition,
• Adult patients protected by law.

Sponsors & Collaborators

• University Hospital, Montpellier: lead

MeSH Terms

Conditions

Neoplasms; Colorectal Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Fanconi Anemia, Complementation Group D1; Genetic Predisposition to Disease

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Endocrine Gland Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 11, 2019
• First Posted: March 26, 2019
• Study Start: August 1, 2012
• Primary Completion: September 1, 2014
• Study Completion: September 1, 2018
• Last Updated: March 28, 2019

Record last verified: 2019-03