Iron Deficiency in Heart Failure Patients

NCT03883854 | Unknown

• 1 other identifier: fh
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Heart failure is a common problem with a prevalence of 1-2% in general population and a major cause of mortality,morbidity and impaired quality of life. Anemia is afrequent comorbidity in stable heart failure patients and it increases morbidity in terms of frequent hospital admissions,impaired exercise capacity,poor quality of life ,and increased mortality

Conditions

Heart Failure

Outcome Measures

Primary Outcomes (1)

• percentage of iron deficiency in systolic heart failure patients

  systolic heart failure is defined as ejection fraction \<50% absolute iron deficiency is serum ferritin\<100ug/l.Functional iron deficiency is defined as normal serum ferritin(100-300)ug/l with low transferrin saturation\<20%

  1 year

Study Arms (1)

1 group

Complete iron profile * serum iron * serum ferritin * total iron binding capacity * transferrin saturation (TSAT)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

all participants will undergoe 1. full history(including dietary history) 2. clinical examination. 3. transthoracic echocardiography:for measurement of ejection fraction 4. complete blood count 5. complete iron profile: serum iron -serum ferritin-total iron binding capacity-transferrin saturation.

You may qualify if:

• males or females patients above age of 18years of age and clinically diagnosed with systolic heart failure,ejection fraction\<50% by echocardiography admitted in Assiut University hospital

You may not qualify if:

• Known to be non cardiac condition causing iron deficiency(haemorrhoids,malignancy).
• other conditions causing fluid overload(eg.renal failure on dialysis ). .congenital heart disease.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Cleland JG, Khand A, Clark A. The heart failure epidemic: exactly how big is it? Eur Heart J. 2001 Apr;22(8):623-6. doi: 10.1053/euhj.2000.2493. No abstract available.

  PMID: 11286518 RESULT

Biospecimen

Retention: NONE RETAINED

Full history (including dietary history) 2)clinical examination. 3)Transthoracic echocardiography : * Transthoracic echocardiography for measurement of ejection fraction by simpson s method 4)Complete blood count. 5)Complete iron profile * serum iron * serum ferritin * total iron binding capacity * transferrin saturation (TSAT) Anemia is defined as hemoglobin (Hb)\<13g/dl for males and \<12 g/dl for females based on world health organization definition (17) Absolute iron deficiency is serum ferritin (100ug/L) Functional iron deficiency is defined as normal serum ferritin (100-300)with low TAST\<20%

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Amr Youssef, MD

CONTACT

0100655404; amryousef111@yahoo.com

Ayman Hassan, MD

CONTACT

0109443805; Ayman.hassan@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 19, 2019
• First Posted: March 21, 2019
• Study Start: March 25, 2019
• Primary Completion: March 26, 2020
• Study Completion: October 20, 2020
• Last Updated: March 22, 2019

Record last verified: 2019-03