Surgery for Gastrointestinal Metastases of Malignant Melanoma - a Single Center Retrospective Cohort Study

NCT03879395 | Completed

• 1 other identifier: SurgMelMet
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to conduct a single centre retrospective study of all patients with stage IV melanoma that underwent surgery for metastases at Sahlgrenska University Hospital between 2010-01-01 and 2018-12-31. Pre- and postoperative data will be collected from digital medical records, the Swedish Cancer Registry, the Swedish Cause of Death Register as well as from the national Swedish cancer patient database (INCA). If needed, patient records will be collected from other hospitals. Results will be presented in written format as a summary and analysis of the characteristics of the cases operated on during the inclusion period. The aim is to identify predictive and prognostic factors for outcome and complications in the surgical treatment of stage IV metastatic melanoma.

Conditions

Melanoma Stage Iv; Melanoma Metastatic; Abdominal Tumor

Keywords

melanoma; abdominal metastasis; metastasectomy; tumor resection; M1c

Outcome Measures

Primary Outcomes (1)

• Overall survival

  Overall survival

  December 2018

Secondary Outcomes (1)

• Complications according to Clavien-Dindo within 90 days.

  90 days

Study Arms (1)

Cohort

Patients with stage IV malignant melanoma with abdominal metastasis (M1c) that underwent abdominal surgery with metastasectomy during the study period.

Procedure: Abdominal surgery with metastasectomy

Interventions

Abdominal surgery with metastasectomy PROCEDURE

Emergency or elective surgery on indications related to abdominally metastasized malignant melanoma

Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with abdominally metastasized malignant melanoma stage IV.

You may qualify if:

• Biopsy verified stage IV malignant melanoma, stage M1c.
• Having undergone surgery with metastasectomy of melanoma tumors.

You may not qualify if:

• retroperitoneal tumors

Sponsors & Collaborators

• Vastra Gotaland Region: lead

Study Sites (1)

Sahlgrenska University Hospital

Gothenburg, 413 45, Sweden

Location

Related Publications (1)

• Holmberg CJ, Alwan G, Ny L, Olofsson Bagge R, Katsarelias D. Surgery for gastrointestinal metastases of malignant melanoma - a retrospective exploratory study. World J Surg Oncol. 2019 Jul 12;17(1):123. doi: 10.1186/s12957-019-1663-z.

  PMID: 31299988 DERIVED

MeSH Terms

Conditions

Melanoma; Abdominal Neoplasms

Interventions

Metastasectomy

Condition Hierarchy (Ancestors)

Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Nerve Tissue; Nevi and Melanomas; Skin Neoplasms; Neoplasms by Site; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Senior Consultant Surgeon

Study Record Dates

• First Submitted: March 15, 2019
• First Posted: March 18, 2019
• Study Start: January 1, 2010
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: January 26, 2024

Record last verified: 2024-01

Locations

SE (1)