NCT03877159

Brief Summary

Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. Caspase-8 is a key enzyme involved in controlling cell death. This study examines the importance of caspase-8 in oral cancer.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2017

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 11, 2017

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

March 11, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 15, 2019

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 30, 2021

Completed
Last Updated

July 22, 2020

Status Verified

July 1, 2020

Enrollment Period

3.2 years

First QC Date

March 11, 2019

Last Update Submit

July 21, 2020

Conditions

Oral Cancer

Outcome Measures

Primary Outcomes (1)

  • Caspase-8 activity in oral cancer and its impact on disease progression

    Molecular analysis of caspase-8 activity will be undertaken and correlated with tumour features and outcome.

    Up to 3 years

Interventions

There is no intervention.OTHER

There is no intervention. This is a retrospective study analysing archived tumour samples.

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Archived oral cancer tissue specimens within this single institute.

You may qualify if:

  • Oral cancer
  • Sufficient follow up data

You may not qualify if:

  • Patient has indicated that they do not wish their tissue to be used for research.
  • The quantity or quality of tissue is too little or poor to provide adequate material without significant reserve.
  • The material contains bone.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Robert Kennedy

London, SE19RT, United Kingdom

RECRUITING

MeSH Terms

Conditions

Mouth Neoplasms

Condition Hierarchy (Ancestors)

Head and Neck NeoplasmsNeoplasms by SiteNeoplasmsMouth DiseasesStomatognathic Diseases

Study Officials

  • Robert Kennedy, BSc PhD BDS

    KCL

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Robert Kennedy, BSc PhD BDS

CONTACT

07815501088robert.kennedy@kcl.ac.uk

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 11, 2019

First Posted

March 15, 2019

Study Start

November 11, 2017

Primary Completion

January 30, 2021

Study Completion

January 30, 2021

Last Updated

July 22, 2020

Record last verified: 2020-07

Data Sharing

IPD Sharing
Will not share

No patient identifiable data is stored

Locations

GB(1)