Investigation of Environmental Factors Associated With Transmission of T. Solium in Endemic Villages of Zambia

NCT03874689 | Completed

• 1 other identifier: TEPIM
• Study Type: observational
• Target: 2,921
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to determine the prevalence of taeniosis and (neuro)cysticercosis in two districts in the southern (Gwembe) and eastern province (Chipata) of Zambia.

Conditions

Neurocysticercosis; Taeniosis

Keywords

Neurocysticercosis

Outcome Measures

Primary Outcomes (3)

• Prevalence of T. solium cysticercosis

  Prevalence of human T. solium cysticercosis

  Assessment through blood sampling at baseline

• Prevalence of neurocysticercosis

  Prevalence of human neurocysticercosis among people with positive serology for T. solium cysticercosis

  Assessment at CT scanning at baseline

• Prevalence of taeniosis

  Prevalence of human T. solium taeniosis

  Assessment through stool sampling at baseline

Secondary Outcomes (1)

• Prevalence of intestinal helminth infection

  Assessment through stool sampling at baseline

Eligibility Criteria

• Age: 10 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Study participants will be sampled from villages of two districts in Sambia (Gwembe and Chipata). Villages of these districts will be selected at random and all people from these villages will be invited to take part in the study. No selection apart from the exclusion criteria will take place.

You may qualify if:

• Willing and able to participate in all aspects of the study, including providing blood and stool samples, participating in a questionnaire survey and group discussions, and taking oral anthelmintic tablets
• Willing and able to provide informed consent (signature or thumbprint with impartial witness; assent for minors with parental consent).
• Living in, attending school in, or regularly visiting the bore holes present in, the study communities.
• Aged 10 years or older

You may not qualify if:

• Unwilling or unable to participate in some or all aspects of the study, including providing blood and stool samples, participating in a questionnaire survey and group discussions, or taking oral anthelmintic tablets.
• Unwilling or unable to provide written (signature or thumbprint with impartial witness) informed consent (or assent for minors).
• Living outside of, and not regularly visiting, or attending school in, the study communities.
• Children aged less than 10 years.
• Seriously ill individuals (people unable to engage in the normal activities of daily living without assistance because of their illnesses).

Sponsors & Collaborators

• Technical University of Munich: lead

Study Sites (1)

University of Zambia

Lusaka, 32379, Zambia

Location

Related Publications (1)

• Zulu G, Sikasunge CS, Welte TM, Simuunza MC, Stelzle D, Schmidt V, Hachangu A, Mutale W, Masuku M, Chembensofu M, da Costa CP, Mwape KE, Winkler AS, Phiri IK. Epidemiology of intestinal helminthiasis with an emphasis on taeniasis in Chipata district of the Eastern province of Zambia. PLoS Negl Trop Dis. 2023 Nov 20;17(11):e0011561. doi: 10.1371/journal.pntd.0011561. eCollection 2023 Nov.

  PMID: 37983246 RESULT

Related Links

• Epidemiology of intestinal helminthiasis with an emphasis on taeniasis in Chipata district of the Eastern province of Zambia

Biospecimen

Retention: SAMPLES WITH DNA

Blood and stool sample

MeSH Terms

Conditions

Neurocysticercosis

Condition Hierarchy (Ancestors)

Central Nervous System Helminthiasis; Central Nervous System Parasitic Infections; Central Nervous System Infections; Infections; Parasitic Diseases; Cysticercosis; Taeniasis; Cestode Infections; Helminthiasis; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Chummy S. Sikasunge, PhD

  University of Zambia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2019
• First Posted: March 14, 2019
• Study Start: June 1, 2019
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: November 30, 2023

Record last verified: 2023-11

Locations

ZA (1)