Resistance Exercise and Cannabis Use

NCT03867786 | Unknown

• 1 other identifier: 12345
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. The highest rates of use and CUDs are seen in young adults (20 - 24 years old) with more than 50% of young adults reporting lifetime use of cannabis, 35% report use in the past year, and 20% report use in the past month. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of cannabis use and associated risks, identifying effective behavioral strategies that reduce cannabis craving, negative psychological effects, and alter neurobiological mechanisms underlying problematic cannabis use are an avenue of needed research. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD.

Conditions

Cannabis Use Disorder

Keywords

Resistance Exercise Neurobiological Mechanisms

Outcome Measures

Primary Outcomes (3)

• Cannabis Craving

  Craving Marijuana Craving Questionnaire (MCQ) The 45-item MCQ is a multi-dimensional questionnaire that assesses marijuana craving. It is based on the the Cocaine Craving Questionnaire and uses items that touch on four specific constructs characterizing craving for marijuana: (1) compulsivity, an inability to control marijuana use; (2) emotionality, use of marijuana in anticipation of relief from withdrawal or negative mood; (3) expectancy, anticipation of positive outcomes from smoking marijuana; and (4) purposefulness, intention and planning to use marijuana for positive outcomes. Each item is rated on a seven-point Likert-type scale ranging from "strongly agree to strongly disagree"

  change from baseline

• Cannabis Craving

  Total Ghrelin as measured by 0.5mL plasma

  Change from baseline

• Cannibis Consumption

  endocannabinoid N-arachidonoylethanolamine (AEA)

  change from Baseline

Study Arms (2)

Exercise Condition

EXPERIMENTAL

Participants will undergo a 40 minute exercise protocol

Behavioral: Exercise

Video Control Condition

ACTIVE COMPARATOR

Participants will view a 40 minute nature video

Behavioral: Video Control

Interventions

Exercise BEHAVIORAL

Participants will complete an acute exercise visit.

Exercise Condition

Video Control BEHAVIORAL

Participants will complete a video control visit.

Video Control Condition

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals between the ages of 18-30 years who currently meet for a moderate or severe cannabis use disorder according to DSM-5 criteria.
• Untrained (no structured exercise program for at least the previous 6 months) as verified by self-report on a physical activity form.
• No previous bone or muscle problems or previous injuries that would prevent free movement about the shoulder, hip, knee or ankle, or increase the risk of discomfort or injury during exercise. No ongoing back problems.
• No known endocrine disorders (including, but not limited to Hyperthyroidism, Hypothyroidism, Hyperparathyroidism, Cushing's Syndrome, Diabetes mellitus, metabolic syndrome or other inflammatory disorders).
• No history of blood clotting disorders.
• Able to read English and complete study assessments
• Voluntarily provide informed consent and sign the informed consent document.
• Able to provide negative toxicology screenings for substances, except for cannabis, at intake.

You may not qualify if:

• Meet current criteria for a moderate or severe substance use disorder for any other substance besides cannabis
• Have any current psychiatric disorders with acute symptoms (i.e., psychosis, suicidal, homicidal, current mania).
• Younger or older than the specified age range of 18-30.
• Any endocrine, bone, muscle problems, previous injuries, back problems, or blood clotting disorders.
• Cardiac and severe respiratory illnesses (i.e. arrhythmias, enlarged heart, COPD) -

Sponsors & Collaborators

• Penn State University: lead

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Gwendolyn Thomas, PhD

CONTACT

8148633172; gat112@psu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Research Professor, Kinesiology

Study Record Dates

• First Submitted: February 11, 2018
• First Posted: March 8, 2019
• Study Start: February 1, 2023
• Primary Completion: August 31, 2023
• Study Completion: December 1, 2024
• Last Updated: January 20, 2023

Record last verified: 2023-01