Micro-RNA Profile in Patients With Different Stages of Atherosclerosis According to CTA

NCT03855891 | Completed

• 1 other identifier: 1741909-2019
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this single-center study is to determine the spectrum and levels of cardiospecific circulating microRNAs in patients with different stages of atherosclerosis according to 640-slice multispiral computed tomography (MSCT).

Conditions

Ischemic Heart Disease; Atherosclerosis

Keywords

Ischemic Heart Disease; Atherosclerosis; micro-RNA; multislice spiral computed tomography; coronary angiography

Outcome Measures

Primary Outcomes (1)

• Determination of the profile of circulating microRNAs in patients with different degrees of severity of atherosclerotic process on the MSCT criteria basis.

  Analysis of the spectrum and levels of cardiospecific circulating microRNAs in patients with different degrees of severity of atherosclerotic process on the MSCT criteria basis.

  2 days

Study Arms (1)

Study group

EXPERIMENTAL

A group of patients with blood tests

Diagnostic Test: blood test

Interventions

blood test DIAGNOSTIC_TEST

Blood test for spectrum and level of cardiospecific micro-RNA

Study group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Written informed consent of the patient to participate in the study;
• Age 18-80;
• The presence of medical indications for MSCT angiography of coronary arteries in connection with suspected coronary heart disease.

You may not qualify if:

• Age less than 18 or more than 80;
• Pregnancy, breast-feeding;
• Patients who have not undergone (and do not plan) MSCT coronary angiography;
• Any surgical intervention on the heart in history;
• Severe heart failure (III-IV NYHA classes);
• History of myocardial infarction;
• The body mass index of 35 or more;
• More than twice the ALT and/or AST level;
• The presence of severe somatic pathology (except coronary atherosclerosis);
• Patient's refusal to participate in the study;

Sponsors & Collaborators

• I.M. Sechenov First Moscow State Medical University: lead

Study Sites (1)

IMSechenovMMA

Moscow, 119991, Russia

Location

MeSH Terms

Conditions

Myocardial Ischemia; Atherosclerosis

Interventions

Hematologic Tests

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Philipp Kopylov, Professor

  Sechenov Univercity

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post-graduate student of Department of of Preventive and Emergency Cardiology I.M. Sechenov First Moscow State Medical University

Study Record Dates

• First Submitted: February 25, 2019
• First Posted: February 27, 2019
• Study Start: January 1, 2019
• Primary Completion: August 14, 2020
• Study Completion: October 1, 2020
• Last Updated: December 22, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

RU (1)