C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies

NCT03650790 | Completed DMC

• 1 other identifier: DiyarbakirWCDH
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric oxide synthesis (eNOS). The aim of this study was to investigate CTRP-9 levels in pregnant women with preeclampsia.

Conditions

Pre-Eclampsia; Obesity; Endocrine

Keywords

CTRP; Adipocytokines; pre-eclampsia

Outcome Measures

Primary Outcomes (1)

• CTRP 9 level in preeclamptic pregnancies

  Blood samples were taken from patients with preeclampsia. The diagnosis was made when the arterial blood pressure was above 140/90 mm / Hg within 6 hours and was accompanied by proteinuria (\> 300 milligrams in a sample) with high blood pressure and number of patients with proteinuria (ACOG criteria)

  3 months

Study Arms (3)

preeclamptic obese pregnancy

ACTIVE COMPARATOR

CTRP 9 level will be assessed by 40 obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.

Diagnostic Test: Blood test

preeclamptic non-obese pregnancy

ACTIVE COMPARATOR

CTRP 9 level will be assessed by 40 non-obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.

Diagnostic Test: Blood test

normal pregnancy

ACTIVE COMPARATOR

CTRP 9 level will be assessed by 40 normal gestational ELISA methods

Diagnostic Test: Blood test

Interventions

Blood test DIAGNOSTIC_TEST

For serum analysis, approximately 2 cc antecubital vein venous blood serum will be taken from each patient to be studied for CTRP9 Level analysis. Adult blood will be centrifuged at 4000 rpm for 10 minutes to separate greenhouses. The obtained serum samples will be stored at -80 ° C until analysis.

normal pregnancy; preeclamptic non-obese pregnancy; preeclamptic obese pregnancy

Eligibility Criteria

• Age: 15 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Pregnant women who are ages 15-40
• BMI ≥35 kg/m2 and BMI\<25 KG/m2 pregnants
• The clinical diagnosis of preeclampsia will follow the current criteria outlined by ACOG 10
• \> 20 th weeks of pregnancy

You may not qualify if:

• A previously known chronic metabolic disease (diabetes, pregestational dyslipidemia, hypertension,)
• collagen vascular diseases,
• inflammatory bowel disease
• chronic inflammatory conditions,

Sponsors & Collaborators

• Diyarbakir Women's and Children's Diseases Hospital: lead

Study Sites (1)

Diyarbakır Women's and Children's Hospital

Diyarbakır, 21100, Turkey (Türkiye)

Location

Related Links

• Preeclampsia relationship of adipocytokines
• Relation to CTRP 9 vasodilatation

MeSH Terms

Conditions

Pre-Eclampsia; Obesity

Interventions

Hematologic Tests

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Şerif Aksin, specialist

  Diyarbakir Women's and Children's Diseases Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist doctor

Model Details: 40 obese preeclamptic pregnant women 40 non-obese preeclamptic pregnant women 40 normal pregnant women

Study Record Dates

• First Submitted: August 27, 2018
• First Posted: August 29, 2018
• Study Start: September 3, 2018
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: January 8, 2019

Record last verified: 2019-01

Locations

TU (1)