NCT03855137

Brief Summary

This study evaluated the efficacy, safety and tolerability of atogepant in participants with chronic migraine. This study included a 12-week treatment period.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
778

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Mar 2019

Typical duration for phase_3

Geographic Reach
17 countries

150 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 25, 2019

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 26, 2019

Completed
13 days until next milestone

Study Start

First participant enrolled

March 11, 2019

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 20, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 20, 2022

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

February 14, 2023

Completed
Last Updated

February 14, 2023

Status Verified

January 1, 2023

Enrollment Period

2.9 years

First QC Date

February 25, 2019

Results QC Date

January 18, 2023

Last Update Submit

January 18, 2023

Conditions

Outcome Measures

Primary Outcomes (2)

  • Change From Baseline in Mean Monthly Migraine Days Across 12-Week Treatment Period in mITT Population

    Participants recorded daily duration of migraine in a diary. A migraine day was any calendar day on which the participant experienced a migraine headache. The monthly (4-week) migraine days were defined as the total number of reported migraine days in diary divided by total number of days with diary records during each 4-week period and multiplied by 28. Each 4-week period was averaged. Baseline is defined as the number of migraine days during the last 28 days prior to the randomization date. Negative change from Baseline indicates improvement. A contrast from Mixed-effects model for repeated measures (MMRM) was used to obtain the average treatment effects across the 12-week treatment period.

    Baseline to Week 12

  • Change From Baseline in Mean Monthly Migraine Days Across 12-Week Treatment Period in Off-Treatment Hypothetical Estimand Population

    Participants recorded daily duration of migraine in a diary. A migraine day was any calendar day on which the participant experienced a migraine headache. The monthly (4-week) migraine days were defined as the total number of reported migraine days in diary divided by total number of days with diary records during each 4-week period and multiplied by 28. Each 4-week period was averaged. Baseline is defined as the number of migraine days during the last 28 days prior to the randomization date. Negative change from Baseline indicates improvement. A contrast from Mixed-effects model for repeated measures (MMRM) was used to obtain the average treatment effects across the 12-week treatment period.

    Baseline to Week 12

Secondary Outcomes (10)

  • Change From Baseline in Mean Monthly Headache Days Across 12-Week Treatment Period in mITT Population

    Baseline to Week 12

  • Change From Baseline in Mean Monthly Headache Days Across 12-Week Treatment Period in Off-Treatment Hypothetical Estimand Population

    Baseline to Week 12

  • Change From Baseline in Mean Monthly Acute Medication Use Days Across 12-Week Treatment Period in mITT Population

    Baseline to Week 12

  • Change From Baseline in Mean Monthly Acute Medication Use Days Across 12-Week Treatment Period in Off-treatment Hypothetical Estimand Population

    Baseline to Week 12

  • Percentage of Participants With at Least a 50% Reduction in 3-Month Average of Monthly Migraine Days in mITT Population

    Baseline to Week 12

  • +5 more secondary outcomes

Study Arms (3)

Placebo

PLACEBO COMPARATOR

Participants received atogepant-matching placebo tablets, orally, twice daily (BID) for 12 weeks in a double-blind (DB) treatment period.

Drug: Placebo

Atogepant 30 mg BID

ACTIVE COMPARATOR

Participants received atogepant 30 mg tablet, orally, BID and atogepant-matching placebo tablets orally, BID for up to 12 weeks in a DB treatment period.

Drug: Atogepant 30 mgDrug: Placebo

Atogepant 60 mg QD

ACTIVE COMPARATOR

Participants received atogepant 60 mg, orally, once daily (QD) along with atogepant-matching placebo 30 mg as morning dose followed by atogepant-matching placebo 30 mg and 60 mg as evening doses for up to 12 weeks in a DB treatment period.

Drug: Atogepant 60 mgDrug: Placebo

Interventions

Tablets containing 30 mg atogepant

Atogepant 30 mg BID

Tablets containing 60 mg atogepant

Atogepant 60 mg QD

30 mg/60 mg tablets containing atogepant-matching placebo

Atogepant 30 mg BIDAtogepant 60 mg QDPlacebo

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • At least a 1-year history of chronic migraine (CM) consistent with a diagnosis according to the International Classification of Headache Disorders, 3rd Edition (ICHD-3), 2018
  • Age of the participant at the time of migraine onset \< 50 years
  • Confirmation of headache/migraine headache day frequency as follows:
  • History of, on average, ≥ 15 headache days per month in the 3 months prior to Visit 1 in the opinion of the investigator AND
  • \>=15 headache days during the 4-week screening/baseline period per the electronic diary (eDiary) AND
  • \>=8 days during the 4-week screening/baseline period that qualify as being a migraine day per the eDiary
  • Participants must be using a medically acceptable and effective method of birth control during the course of the entire study

You may not qualify if:

  • Has a history of migraine, accompanied by diplopia or decreased level of consciousness, or retinal migraine
  • Has a current diagnosis of new persistent daily headache, trigeminal autonomic cephalgia (eg, cluster headache), or painful cranial neuropathy
  • History of an inadequate response to \> 4 medications (2 of which have different mechanisms of action) prescribed for the prevention of migraine
  • Woman is pregnant, planning to become pregnant during the course of the study, or currently lactating. Women of childbearing potential must have a negative urine pregnancy test at Visit 1 and Visit 2.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (150)

Barrow Neuro Institute /ID# 236776

Phoenix, Arizona, 85013, United States

Location

Baptist Health Center for Clinical Research /ID# 237361

Little Rock, Arkansas, 72205, United States

Location

California Headache and Balance Center /ID# 236246

Fresno, California, 93720, United States

Location

Wr-Pri Llc /Id# 236008

Los Alamitos, California, 90720, United States

Location

Pharmacology Research Institute (PRI) - Newport Beach (Wake) /ID# 237692

Newport Beach, California, 92660, United States

Location

Schuster Medical Research Institute /ID# 236447

Sherman Oaks, California, 91403, United States

Location

Alpine Clinical Research Center /ID# 234346

Boulder, Colorado, 80301-1880, United States

Location

George Washington University Medical Faculty Associates /ID# 238011

Washington D.C., District of Columbia, 20037-3201, United States

Location

Accel Research Sites - St Petersburg Clinical Research Unit /ID# 237161

St. Petersburg, Florida, 33709-3113, United States

Location

Accel Research Sites - Tampa Clinical Research Unit /ID# 237485

Tampa, Florida, 33634, United States

Location

Premiere Research Institute - Palm Beach /ID# 238192

West Palm Beach, Florida, 33407-3209, United States

Location

NeuroTrials Research Inc. /ID# 237364

Atlanta, Georgia, 30328, United States

Location

Josephson-Wallack-Munshower Neurology - NE /ID# 238234

Indianapolis, Indiana, 46256-4692, United States

Location

Collective Medical Research /ID# 236400

Prairie Village, Kansas, 66208, United States

Location

Ochsner Clinic Foundation /ID# 236543

Covington, Louisiana, 70433-8107, United States

Location

Beth Israel Deaconess Medical Center /ID# 237540

Boston, Massachusetts, 02215-5400, United States

Location

BTC of New Bedford /ID# 236384

New Bedford, Massachusetts, 02740, United States

Location

Clinical Research Institute, Inc /ID# 238299

Minneapolis, Minnesota, 55402-2606, United States

Location

Headache Neurology Research Institute /ID# 236464

Ridgeland, Mississippi, 39157, United States

Location

Nevada Headache Institute /ID# 236420

Las Vegas, Nevada, 89113, United States

Location

Dartmouth-Hitchcock Medical Center /ID# 237444

Lebanon, New Hampshire, 03756, United States

Location

Albuquerque Clinical Trials, Inc /ID# 236853

Albuquerque, New Mexico, 87102, United States

Location

Albany Medical Center Rheumatology /ID# 236540

Albany, New York, 12208-3412, United States

Location

Dent Neurosciences Research Center, Inc. /ID# 237040

Amherst, New York, 14226, United States

Location

Headache Wellness Center /ID# 236431

Greensboro, North Carolina, 27405, United States

Location

Raleigh Neurology Associates /ID# 237141

Raleigh, North Carolina, 27607, United States

Location

Stetson-University of Cincinnati /ID# 236453

Cincinnati, Ohio, 45219, United States

Location

Abington Neurological Associates - Abington /ID# 236258

Abington, Pennsylvania, 19001, United States

Location

Preferred Primary Care Physicians, Inc. /ID# 236439

Pittsburgh, Pennsylvania, 15236, United States

Location

WR-ClinSearch /ID# 238288

Chattanooga, Tennessee, 37421-1605, United States

Location

Clinical Neuroscience Solutions - Memphis /ID# 237478

Memphis, Tennessee, 38119, United States

Location

DiscoveResearch, Inc /ID# 236274

Bryan, Texas, 77802, United States

Location

Texas Neurology /ID# 236359

Dallas, Texas, 75214, United States

Location

University of Texas Southwestern Medical Center /ID# 236941

Dallas, Texas, 75390-7208, United States

Location

J. Lewis Research, Inc. / Foothill Family Clinic /ID# 236395

Salt Lake City, Utah, 84109, United States

Location

J. Lewis Research, Inc. Foothill Family Clinic South /ID# 236297

Salt Lake City, Utah, 84121, United States

Location

Highland Clinical Research /ID# 237816

Salt Lake City, Utah, 84124, United States

Location

MedStar Georgetown Neurology /ID# 236324

McLean, Virginia, 22101, United States

Location

Sentara Neurology Specialists - Virginia Beach /ID# 234349

Virginia Beach, Virginia, 23456-0019, United States

Location

Northwest Clinical Research Center /ID# 237581

Bellevue, Washington, 98007, United States

Location

Puget Sound Neurology /ID# 236321

Tacoma, Washington, 25328, United States

Location

Royal North Shore Hospital /ID# 237008

St Leonards, New South Wales, 2065, Australia

Location

The Royal Melbourne Hospital /ID# 236859

Parkville, Victoria, 3050, Australia

Location

CHAMP Clinic /ID# 236252

Calgary, Alberta, T3M 1M4, Canada

Location

Vancouver Island Health Authority /ID# 238053

Victoria, British Columbia, V8R 1J8, Canada

Location

Ottawa Headache Centre Research Inc /ID# 236432

Ottawa, Ontario, K2G 6E2, Canada

Location

Clinique des cephalees de Montreal /ID# 236266

Montreal, Quebec, H2W 1V1, Canada

Location

Montreal Neurological Institut /ID# 236329

Montreal, Quebec, H3A 2B4, Canada

Location

Peking University Third Hospital /ID# 238150

Beijing, Beijing Municipality, 100191, China

Location

Chinese PLA General Hospital /ID# 238237

Beijing, Beijing Municipality, 100853, China

Location

Guangzhou First People's Hospital /ID# 236510

Guangzhou, Guangdong, 510180, China

Location

The Second Affiliated Hospital of Guangzhou Medical University /ID# 238133

Guangzhou, Guangdong, 510260, China

Location

Hubei General Hospital /ID# 236486

Wuhan, Hebei, 430060, China

Location

The First Affiliated Hospital of Zhengzhou University /ID# 237025

Zhengzhou, Henan, 450052, China

Location

Jiangsu Province Hospital /ID# 237846

Nanjing, Jiangsu, 210029, China

Location

The Second Hospital of Jilin University /ID# 236520

Changchun, Jilin, 130022, China

Location

Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 237847

Shanghai, Shanghai Municipality, 200065, China

Location

The Second Hospital of Shanxi Medical University /ID# 236529

Taiyuan, Shanxi, 030000, China

Location

The second Affiliated hospital of Zhejiang University school of Medicine /ID# 238260

Hangzhou, Zhejiang, 310009, China

Location

Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 236500

Hangzhou, Zhejiang, 310020, China

Location

Beijing Friendship Hospital /ID# 237264

Beijing, 100032, China

Location

The Second Hospital of Soochow University /ID# 234296

Suzhou, 215004, China

Location

Tianjin Huanhu Hospital (THH) /ID# 236524

Tianjin, 300350, China

Location

Tongji Hospital Tongji Medical College of HUST /ID# 237835

Wuhan, 430030, China

Location

NEUROHK s.r.o. /ID# 236290

Hradec Králové, 500 09, Czechia

Location

BRAIN-SOULTHERAPY s.r.o. /ID# 236380

Kladno, 272 01, Czechia

Location

CCR Ostrava, s.r.o. /ID# 234291

Ostrava, 702 00, Czechia

Location

CLINTRIAL s.r.o. /ID# 237793

Prague, 100 00, Czechia

Location

CCR Prague s.r.o. /ID# 236250

Prague, 130 00, Czechia

Location

CCR Czech a.s /ID# 236249

Prague, 140 00, Czechia

Location

Thomayerova nemocnice /ID# 237175

Prague, 140 59, Czechia

Location

FORBELI s.r.o. /ID# 236427

Prague, 160 00, Czechia

Location

NeuroMed Zlin s.r.o. /ID# 236416

ZlĂ­n, 760 01, Czechia

Location

Rigshospitalet Glostrup /ID# 236411

Glostrup Municipality, Capital Region, 2600, Denmark

Location

AP-HM - Hopital de la Timone /ID# 236285

Marseille, Bouches-du-Rhone, 13385, France

Location

CH Annecy Genevois Site Annecy /ID# 236385

Pringy, Haute-Savoie, 74374, France

Location

HĂ´pital Pierre Wertheimer /ID# 236969

Bron, 69677, France

Location

CHU Gabriel Montpied /ID# 237323

Clermont-Ferrand, 63000, France

Location

Charite Universitaetsklinikum Berlin - Campus Virchow /ID# 237256

Berlin, 13353, Germany

Location

Praxis Dr. Gendolla /ID# 236311

Essen, 45133, Germany

Location

Universitaetsklinikum Essen /ID# 237209

Essen, 45147, Germany

Location

CTC North GmbH & Co. KG /ID# 236328

Hamburg, 20251, Germany

Location

Vitos Orthopaedische Klinik Kassel gemeinnuetzige GmbH /ID# 236723

Kassel, 34131, Germany

Location

Schmerzklinik Kiel /ID# 236444

Kiel, 24149, Germany

Location

LMU Klinikum Campus Grosshadern /ID# 236293

MĂĽnchen, 81377, Germany

Location

Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 237492

Bari, 70124, Italy

Location

Azienda Ospedaliero Universitaria Careggi /ID# 237598

Florence, 50134, Italy

Location

Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 237291

Milan, 20133, Italy

Location

AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 236361

Napoli, 80138, Italy

Location

Universita di Pavia /ID# 236363

Pavia, 27100, Italy

Location

IRCCS San Raffaele Pisana /ID# 236552

Rome, 00163, Italy

Location

Takanoko Hospital /ID# 234564

Matsuyama, Ehime, 790-0925, Japan

Location

Fukuiken Saiseikai Hospital /ID# 236794

Fukui-shi, Fukui, 918-8235, Japan

Location

Higashi Sapporo Neurology and Neurosurgery Clinic /ID# 234549

Sapporo, Hokkaido, 003-0003, Japan

Location

Konan Medical Center /ID# 236230

Kobe, HyĹŤgo, 658-0064, Japan

Location

Atsuchi Neurosurgical Hospital /ID# 234779

Kagoshima, Kagoshima-ken, 892-0842, Japan

Location

Tokai University Hospital /ID# 237595

Isehara-shi, Kanagawa, 259-1193, Japan

Location

Fujitsu Clinic /ID# 237443

Kawasaki-shi, Kanagawa, 211-8588, Japan

Location

Umenotsuji Clinic /ID# 234495

Kochi, Kochi, 780-8011, Japan

Location

Sendai Headache and Neurology Clinic Medical Corporation /ID# 234496

Sendai, Miyagi, 982-0014, Japan

Location

Saitama Medical University Hospital /ID# 237019

Iruma-gun, Saitama, 350-0495, Japan

Location

Saitama Neuropsychiatric Institute /Id# 234550

Saitama-shi, Saitama, 338-8577, Japan

Location

Japanese Red Cross Shizuoka Hospital /ID# 234372

Shizuoka, Shizuoka, 420-0853, Japan

Location

Dokkyo Medical University Hospital /ID# 236810

Shimotsuga-gun, Tochigi, 321-0293, Japan

Location

Niwa Family Clinic /ID# 234552

Chofu-shi, Tokyo, 182-0006, Japan

Location

Tokyo Headache Clinic /ID# 234555

Shibuya-ku, Tokyo, 151-0051, Japan

Location

Keio University Hospital /ID# 237210

Shinjuku-ku, Tokyo, 160-8582, Japan

Location

Nagaseki Headache Clinic /ID# 234561

Kai-shi, Yamanashi, 400-0124, Japan

Location

DOI Internal Medicine-Neurology Clinic /ID# 234562

Hiroshima, 730-0031, Japan

Location

Hiroshima Neurology Clinic /ID# 234563

Hiroshima, 732-0822, Japan

Location

Tanaka Neurosurgical clinic /ID# 234760

Kagoshima, 892-0844, Japan

Location

Tatsuoka Neurology Clinic /ID# 234782

Kyoto, 600-8811, Japan

Location

Tominaga Hospital /ID# 234781

Osaka, 556-0017, Japan

Location

Shinagawa Strings Clinic /ID# 234780

Tokyo, 108-0075, Japan

Location

Solumed Centrum Medyczne /ID# 236452

Poznan, Greater Poland Voivodeship, 60-529, Poland

Location

NZOZ Vitamed /ID# 237041

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079, Poland

Location

Specjalistyczne Gabinety Sp. z o.o. /ID# 236348

Krakow, Lesser Poland Voivodeship, 30-539, Poland

Location

Centrum Leczenia Padaczki i Migreny /ID# 236386

Krakow, Lesser Poland Voivodeship, 31-209, Poland

Location

Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej /ID# 236289

Lublin, Lublin Voivodeship, 20-582, Poland

Location

Centrum Medyczne Pratia Gdynia /ID# 237077

Gdynia, Pomeranian Voivodeship, 81-338, Poland

Location

Silmedic Sp. z o.o. /ID# 237343

Katowice, Silesian Voivodeship, 40-282, Poland

Location

EuroMedis sp. z o.o. /ID# 236417

Szczecin, West Pomeranian Voivodeship, 70-111, Poland

Location

Kazan State Medical University /ID# 236298

Kazan', Tatarstan, Respublika, 420012, Russia

Location

State Autonomous Healthcare Institution Republican Clinical Neurology Centre /ID# 236354

Kazan', Tatarstan, Respublika, 420021, Russia

Location

University Headache Clinic /ID# 236371

Moscow, 119221, Russia

Location

Clinics Chaika /ID# 236394

Moscow, 125047, Russia

Location

Central Clinical Hospital RZHD Medicine /ID# 237024

Moscow, 129128, Russia

Location

Dongtan Sacred Heart Hospital /ID# 238097

Hwaseong, Gyeonggido, 18450, South Korea

Location

Kangbuk Samsung Hospital /ID# 237754

Seoul, Seoul Teugbyeolsi, 03181, South Korea

Location

Yonsei University Health System Severance Hospital /ID# 237839

Seoul, Seoul Teugbyeolsi, 03722, South Korea

Location

Pusan National University Hospital /ID# 237120

Busan, 49241, South Korea

Location

Nowon Eulji Medical Center, Eulji University /ID# 236306

Seoul, 01830, South Korea

Location

Seoul National University Hospital /ID# 237786

Seoul, 03080, South Korea

Location

Samsung Medical Center /ID# 237785

Seoul, 06351, South Korea

Location

Hospital ClĂ­nico Universitario de Santiago-CHUS /ID# 237623

Santiago de Compostela, A Coruna, 15706, Spain

Location

CLINICA UNIVERSIDAD DE NAVARRA-Pamplona /ID# 237645

Pamplona, Navarre, 31008, Spain

Location

Hospital Universitario Vall d'Hebron /ID# 236467

Barcelona, 08035, Spain

Location

Hospital Universitario Virgen del Rocio /ID# 237106

Seville, 41013, Spain

Location

Hospital Clinico Universitario de Valencia /ID# 237400

Valencia, 46010, Spain

Location

Hospital Universitario y Politecnico La Fe /ID# 237087

Valencia, 46026, Spain

Location

Hospital Clinico Universitario de Valladolid /ID# 234406

Valladolid, 47003, Spain

Location

Hospital Clinico Universitario Lozano Blesa /ID# 237373

Zaragoza, 50009, Spain

Location

Stortorgets Neurologmottagning /ID# 236454

Helsingborg, 252 20, Sweden

Location

Kuang-Tien General Hospital /ID# 236309

Taichung, 433, Taiwan

Location

Tainan Sin Lau Hospital /ID# 236358

Tainan, 70142, Taiwan

Location

Chi-Mei Medical Center /ID# 236724

Tainan, 71004, Taiwan

Location

Taipei Veterans General Hosp /ID# 237236

Taipei, 11217, Taiwan

Location

Tri-Service General Hospital /ID# 237657

Taipei, 11490, Taiwan

Location

Walton Centre /ID# 236468

Liverpool, L9 7LJ, United Kingdom

Location

King's College Hospital NHS Foundation Trust /ID# 236301

London, SE5 9RS, United Kingdom

Location

Related Publications (10)

  • Schlachter L, Stodtmann S, Voelkner A, Jonsson F, Lagraauw HM, Boinpally RR. Population Pharmacokinetics of Atogepant for the Prevention of Migraine. Clin Pharmacokinet. 2025 Nov 12. doi: 10.1007/s40262-025-01566-5. Online ahead of print.

  • UpToDate(R). Nurse Pract. 2023 Jul 1;48(7):16. doi: 10.1097/01.NPR.0000000000000072. No abstract available.

  • Goadsby PJ, Jurgens TP, Brand-Schieber E, Nagy K, Liu Y, Boinpally R, Stodtmann S, Trugman JM. Efficacy of ubrogepant and atogepant in males and females with migraine: A secondary analysis of randomized clinical trials. Cephalalgia. 2025 Feb;45(2):3331024251320610. doi: 10.1177/03331024251320610.

  • Lipton RB, Gandhi P, Tassorelli C, Reuter U, Harriott AM, Holle-Lee D, Gottschalk CH, Neel B, Liu Y, Guo H, Stokes J, Nagy K, Dabruzzo B, Smith JH. Early Improvements With Atogepant for the Preventive Treatment of Migraine: Results From 3 Randomized Phase 3 Trials. Neurology. 2025 Jan 28;104(2):e210212. doi: 10.1212/WNL.0000000000210212. Epub 2024 Dec 23.

  • Peterlin BL, Bond DS, Ailani J, Dodick DW, Liu Y, De Abreu Ferreira R, Smith JH, Dabruzzo B, Goadsby PJ, Trugman JM. Weight loss with atogepant during the preventive treatment of migraine: A pooled analysis. Cephalalgia. 2024 Dec;44(12):3331024241299753. doi: 10.1177/03331024241299753.

  • Gottschalk C, Gandhi P, Pozo-Rosich P, Christie S, Tassorelli C, Stokes J, Liu Y, Luo L, Nagy K, Trugman JM, Lipton RB. Effect of preventive treatment with atogepant on quality of life, daily functioning, and headache impact across the spectrum of migraine: Findings from three double-blind, randomized, phase 3 trials. Cephalalgia. 2024 Dec;44(12):3331024241300305. doi: 10.1177/03331024241300305.

  • Goadsby PJ, Friedman DI, Holle-Lee D, Demarquay G, Ashina S, Sakai F, Neel B, Gandhi P, Dabruzzo B, Smith JH, Liu Y, Trugman JM. Efficacy of Atogepant in Chronic Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial. Neurology. 2024 Jul 23;103(2):e209584. doi: 10.1212/WNL.0000000000209584. Epub 2024 Jun 26.

  • Pozo-Rosich P, Ailani J, Ashina M, Goadsby PJ, Lipton RB, Reuter U, Guo H, Schwefel B, Lu K, Boinpally R, Miceli R, De Abreu Ferreira R, McCusker E, Yu SY, Severt L, Finnegan M, Trugman JM. Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Sep 2;402(10404):775-785. doi: 10.1016/S0140-6736(23)01049-8. Epub 2023 Jul 26.

  • Boinpally R, McNamee B, Yao L, Butler M, McGeeney D, Borbridge L, Periclou A. A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single-Dose, Phase 1 Crossover Trial. Clin Pharmacol Drug Dev. 2021 Sep;10(9):1099-1107. doi: 10.1002/cpdd.940. Epub 2021 May 4.

  • Min KC, Kraft WK, Bondiskey P, Colon-Gonzalez F, Liu W, Xu J, Panebianco D, Mixson L, Dockendorf MF, Matthews CZ, Boinpally R. Atogepant Is Not Associated With Clinically Meaningful Alanine Aminotransferase Elevations in Healthy Adults. Clin Transl Sci. 2021 Mar;14(2):599-605. doi: 10.1111/cts.12917. Epub 2020 Nov 24.

Related Links

MeSH Terms

Interventions

atogepant

Results Point of Contact

Title
Global Medical Services
Organization
AbbVie

Study Officials

  • ALLERGAN INC.

    Allergan

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 25, 2019

First Posted

February 26, 2019

Study Start

March 11, 2019

Primary Completion

January 20, 2022

Study Completion

January 20, 2022

Last Updated

February 14, 2023

Results First Posted

February 14, 2023

Record last verified: 2023-01

Data Sharing

IPD Sharing
Will share

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
For details on when studies are available for sharing visit, please refer to the link below.
Access Criteria
Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Use Agreement (DUA). For more information on the process, or to submit a request, visit the following link.
More information

Locations