NCT03845283

Brief Summary

Cardiovascular disease (CVD) is the leading cause of death in the United States. Cardiac rehabilitation (CR) is the main treatment for heart attacks and other types of CVD. It is based on science, it saves money, and it is widely-available. Each session (of which there are a few each week for 3 months) combines supervised exercise and instruction. The goals are to improve overall health and reduce cardiovascular risk in individuals with established CVD. CR produces almost no weight loss (WL); if a person has excess weight while in CR (the majority of participants have overweight or obesity), losing weight could really reduce their risk of having another heart attack. The best treatment available for weight loss, in-person behavioral weight loss interventions (BWLs), produce enough WL that they improve health and disease risk/severity. However, in-person BWLs are too much work to be carried out in CR. A previous fully automated 3-month online program, Rx Weight Loss (RxWL), produced good WL in many different settings. Dr. Goldstein aims to tailor RxWL for use in CR. The study will use the Multiphase Optimization Strategy (MOST) to test innovative eHealth/mHealth intervention components that might work well for people when combined with RxWL. The study will include 160 patients (each randomized to receive 0-4 of the components). The components are: (a) a Fitbit with a goal-setting program; (b) a bite counting device; (c) a Web-based virtual reality (VR) intervention ; and (d) virtual meetings. By the 6-month follow-up, the investigators will know if any of those 4 components helped people lose more weight. If a component produced at least 2% WL, it will be studied further by being included in a new intervention to be tested in the next study.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
198

participants targeted

Target at P50-P75 for not_applicable cardiovascular-diseases

Timeline
Completed

Started May 2019

Longer than P75 for not_applicable cardiovascular-diseases

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 5, 2019

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 19, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

May 2, 2019

Completed
5.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2024

Completed
Last Updated

May 21, 2024

Status Verified

February 1, 2024

Enrollment Period

5.3 years

First QC Date

February 5, 2019

Last Update Submit

May 19, 2024

Conditions

Keywords

Cardiovascular DiseasesObesityMultiphase Optimization StrategyTechnologyWeight LossCardiac Rehabilitation

Outcome Measures

Primary Outcomes (1)

  • Weight Change

    The difference between initial weight and weight at the follow-up assessments. Patients will be asked to step on a scale at the assessment clinic.

    At baseline, 3-, and 6-months after initiating the program

Secondary Outcomes (4)

  • Structured Weekly Moderate-to-Vigorous Physical Activity Minutes

    At baseline, 3-, and 6-months after initiating the program

  • Number of Bites

    At baseline, 3-, and 6-months after initiating the program

  • Weight Control Practices

    At baseline, 3-, and 6-months after initiating the program

  • Weight Loss Self-Efficacy: Weight Efficacy Lifestyle Questionnaire

    At baseline, 3-, and 6-months after initiating the program

Other Outcomes (1)

  • Overall Behavioral Self-Management in Cardiac Rehabilitation

    At baseline, 3-, and 6-months after initiating the program

Study Arms (16)

Physical Activity

EXPERIMENTAL

Participants will receive the core 6-month weight loss program and the tailored intervention to promote structured physical activity.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity Intervention

Core Program

EXPERIMENTAL

Participants will receive the core 6-month weight loss program alone. This program includes weekly lessons for the first 12 weeks and monthly lessons for the remaining 12 weeks. Participants will track their intake, physical activity, and weight, input these data into the system, and received tailored feedback.

Behavioral: Online Behavioral Weight Loss Program

Physical Activity & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Virtual Meetings

Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Virtual Meetings

Physical Activity & Virtual Reality

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, and access to the virtual reality platform for behavioral weight loss skills training.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Virtual Reality

Virtual Reality

EXPERIMENTAL

Participants will receive the core 6-month weight loss program and access to the virtual reality platform for behavioral weight loss skills training.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Virtual Reality

Physical Activity, Virtual Reality, & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, the virtual meetings to support weight loss, and access to the virtual reality platform for behavioral weight loss skills training.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Virtual RealityBehavioral: Virtual Meetings

Virtual Reality & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, access to the virtual reality platform for behavioral weight loss skills training, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Virtual RealityBehavioral: Virtual Meetings

Physical Activity & Bite Counter

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, and the Bite Counter device to reduce dietary intake.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Bite Counter

Bite Counter

EXPERIMENTAL

Participants will receive the core 6-month weight loss program and the Bite Counter device to reduce dietary intake.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Bite Counter

Physical Activity, Bite Counter, & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, the Bite Counter device to reduce dietary intake, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Bite CounterBehavioral: Virtual Meetings

Bite Counter & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the Bite Counter device to reduce dietary intake, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Bite CounterBehavioral: Virtual Meetings

Physical Activity, Bite Counter, & Virtual Reality

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, the Bite Counter device to reduce dietary intake, and access to the virtual reality platform for behavioral weight loss skills training.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Bite CounterBehavioral: Virtual Reality

Bite Counter & Virtual Reality

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the Bite Counter device to reduce dietary intake, and access to the virtual reality platform for behavioral weight loss skills training.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Bite CounterBehavioral: Virtual Reality

Physical Activity, Bite Counter, Virtual Reality & Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the tailored intervention to promote structured physical activity, the Bite Counter device to reduce dietary intake, access to the virtual reality platform for behavioral weight loss skills training, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Physical Activity InterventionBehavioral: Bite CounterBehavioral: Virtual RealityBehavioral: Virtual Meetings

Bite Counter, Virtual Reality, & Virtual Meetings

EXPERIMENTAL

Participants will receive the core 6-month weight loss program, the Bite Counter device to reduce dietary intake, access to the virtual reality platform for behavioral weight loss skills training, and the virtual meetings to support weight loss.

Behavioral: Online Behavioral Weight Loss ProgramBehavioral: Bite CounterBehavioral: Virtual RealityBehavioral: Virtual Meetings

Interventions

A self-guided, online program that helps participants reduce excess calories and gradually increase physical activity.

Bite CounterBite Counter & Virtual MeetingsBite Counter & Virtual RealityBite Counter, Virtual Reality, & Virtual MeetingsCore ProgramPhysical ActivityPhysical Activity & Bite CounterPhysical Activity & Virtual MeetingsPhysical Activity & Virtual RealityPhysical Activity, Bite Counter, & Virtual MeetingsPhysical Activity, Bite Counter, & Virtual RealityPhysical Activity, Bite Counter, Virtual Reality & MeetingsPhysical Activity, Virtual Reality, & Virtual MeetingsVirtual MeetingsVirtual RealityVirtual Reality & Virtual Meetings

An program designed to help participants gradually increase their physical activity and maintain an active lifestyle. The program encourages bouts of moderate-to-vigorous physical activity. Participants in this group will receive a Fitbit Versa to help them monitor their physical activity that they will be advised to wear daily. Participants will receive brief (5-10 minute) lessons weekly for the first 3 months and monthly for the last 3 months.

Physical ActivityPhysical Activity & Bite CounterPhysical Activity & Virtual MeetingsPhysical Activity & Virtual RealityPhysical Activity, Bite Counter, & Virtual MeetingsPhysical Activity, Bite Counter, & Virtual RealityPhysical Activity, Bite Counter, Virtual Reality & MeetingsPhysical Activity, Virtual Reality, & Virtual Meetings
Bite CounterBEHAVIORAL

Participants will receive a Bite Counter device to help them monitor and reduce their within-meal consumption. Participants will be asked to wear the device daily.

Bite CounterBite Counter & Virtual MeetingsBite Counter & Virtual RealityBite Counter, Virtual Reality, & Virtual MeetingsPhysical Activity & Bite CounterPhysical Activity, Bite Counter, & Virtual MeetingsPhysical Activity, Bite Counter, & Virtual RealityPhysical Activity, Bite Counter, Virtual Reality & Meetings
Virtual RealityBEHAVIORAL

This program allows participants to practice behavioral weight loss skills using a virtual reality system compatible with their home device. This program helps patients practice these skills in the following artificial settings: at home, at work, at the gym, and at a party. Each participant will be asked to play through each scene at least once during their participation, though they are encouraged to use the program regularly.

Bite Counter & Virtual RealityBite Counter, Virtual Reality, & Virtual MeetingsPhysical Activity & Virtual RealityPhysical Activity, Bite Counter, & Virtual RealityPhysical Activity, Bite Counter, Virtual Reality & MeetingsPhysical Activity, Virtual Reality, & Virtual MeetingsVirtual RealityVirtual Reality & Virtual Meetings

Participants will attend virtual meetings using their own device. Each virtual meeting focuses on a specific topic that will help patients lose weight. Participants are asked to virtually attend at least 6 meetings during their participation. There is no limit to how many they can attend. The meeting topics will rotate and repeat on a schedule.

Bite Counter & Virtual MeetingsBite Counter, Virtual Reality, & Virtual MeetingsPhysical Activity & Virtual MeetingsPhysical Activity, Bite Counter, & Virtual MeetingsPhysical Activity, Bite Counter, Virtual Reality & MeetingsPhysical Activity, Virtual Reality, & Virtual MeetingsVirtual MeetingsVirtual Reality & Virtual Meetings

Eligibility Criteria

Age21 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • currently a participant in The Miriam Hospital's or Newport Hospital's outpatient phase II cardiac rehabilitation program
  • medical clearance to participate by the Medical Director
  • a body mass index (BMI) between 27-45 kg/m2
  • must have a personal computer in their home with internet access
  • must read and understand English
  • willing to use technology to assist with weight loss

You may not qualify if:

  • currently in another weight loss program
  • taking weight loss medication
  • weight loss of ≥ 5% of body weight in the past 6 months
  • currently pregnant, lactating, \< 6 months post-partum, or plans to become pregnant during the next year
  • report of loss of consciousness on the Physical Activity Readiness Questionnaire
  • New York Heart Association Class IV heart failure
  • heart transplant in the last 3 months
  • receipt of left ventricular assist device in the last 2 months
  • a physician diagnosis of dementia
  • a physician prescription for 24 hours of oxygen therapy daily
  • coronary artery bypass surgery in the last 4 weeks
  • current participation in dialysis
  • inability to walk 1 block without stopping
  • report of conditions that in the opinion of the investigators would render them potentially unlikely to follow the protocol including terminal illness, substance abuse, eating disorder, or other significant psychiatric problems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Weight Control and Diabetes Research Center

Providence, Rhode Island, 02903, United States

Location

MeSH Terms

Conditions

Cardiovascular DiseasesObesityWeight Loss

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBody Weight Changes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 5, 2019

First Posted

February 19, 2019

Study Start

May 2, 2019

Primary Completion

September 1, 2024

Study Completion

September 1, 2024

Last Updated

May 21, 2024

Record last verified: 2024-02

Locations