TAP Blocks vs. IV Lidocaine for Kidney Transplants
A Comparison of Transversus Abdominis Plane Blocks Versus Continuous Intravenous Lidocaine for Kidney Transplant Surgery
1 other identifier
interventional
124
1 country
1
Brief Summary
This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2 postoperative-pain
Started Apr 2019
Longer than P75 for phase_2 postoperative-pain
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 14, 2019
CompletedFirst Posted
Study publicly available on registry
February 18, 2019
CompletedStudy Start
First participant enrolled
April 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2021
CompletedJuly 17, 2019
July 1, 2019
1.9 years
February 14, 2019
July 15, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Opioid Consumption
Total opioid utilization
0-24 Hours
Secondary Outcomes (5)
Pain Scores
0-48 Hours
Opioid Consumption
24-48 Hours
Opioid-Related Adverse Events
0-48 Hours
Block/Infusion-Related Adverse Events
0-48 Hours
Opioid Usage
30 days from discharge
Study Arms (2)
TAP Block
ACTIVE COMPARATORSingle-injection transversus abdominis plane block
IV Lidocaine
ACTIVE COMPARATORContinuous intravenous lidocaine infusion
Interventions
Single-injection transversus abdominis plane block with 30 mL of 0.25% Bupivacaine with 1:400,000 epinephrine
Continuous intravenous lidocaine infusion
Eligibility Criteria
You may qualify if:
- Kidney transplant recipient
- \>18 years old
- Consent to participate
You may not qualify if:
- \<18 years old
- Refusal to participate
- Chronic opioid use
- Seizure disorder
- Allergy to local anesthestics
- Severe hepatic disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
Related Publications (1)
Hanson NA, Strunk J, Saunders G, Cowan NG, Brandenberger J, Kuhr CS, Oryhan C, Warren DT, Slee AE, Strodtbeck W. Comparison of continuous intravenous lidocaine versus transversus abdominis plane block for kidney transplant surgery: a randomized, non-inferiority trial. Reg Anesth Pain Med. 2021 Nov;46(11):955-959. doi: 10.1136/rapm-2021-102973. Epub 2021 Aug 20.
PMID: 34417343DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Neil A Hanson, MD
Virginia Mason Medical Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Anesthesiologist
Study Record Dates
First Submitted
February 14, 2019
First Posted
February 18, 2019
Study Start
April 1, 2019
Primary Completion
March 1, 2021
Study Completion
September 1, 2021
Last Updated
July 17, 2019
Record last verified: 2019-07
Data Sharing
- IPD Sharing
- Will not share