NCT03839186

Brief Summary

This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding individual treatment in clinic, promoting the development of precision the medicine.The anesthesia medication during perioperative period is more and more accurate,reasonable and safe, so as to improve the satisfaction of the patients and their families in the perioperative period, to ensure the safety of patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
223

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2016

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2016

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

December 13, 2017

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2018

Completed
3 months until next milestone

First Posted

Study publicly available on registry

February 15, 2019

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2019

Completed
Last Updated

March 2, 2022

Status Verified

March 1, 2018

Enrollment Period

2.3 years

First QC Date

December 13, 2017

Last Update Submit

February 27, 2022

Conditions

Drug ReactionAnestheticHemodynamic ReboundGene

Keywords

personalized medicinegenetic polymorphismpharmacogeneticshemodynamic change

Outcome Measures

Primary Outcomes (1)

  • Genotyping results of anesthetic drugs

    Genotype information of SNP related to anesthetic drug metabolism, such as AA, AG or GG

    one year

Secondary Outcomes (1)

  • vital signs

    one year

Other Outcomes (2)

  • depth of anesthesia

    one year

  • prognostic indicator

    one year

Eligibility Criteria

Age20 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients from department of thoracic and cardiovascular surgery in Xiangya Hospital, Central South University

You may qualify if:

  • Undergoing general anesthesia
  • Undergoing Cardiovascular surgery

You may not qualify if:

  • ASA granding more than five
  • Severe organ dysfunction

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Xiangya Hospital of Central South University

Changsha, Hunan, 410000, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Drug-Related Side Effects and Adverse Reactions

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders

Study Officials

  • e wang, doctor

    Xiangya Hospital of Central South University

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 13, 2017

First Posted

February 15, 2019

Study Start

August 1, 2016

Primary Completion

December 1, 2018

Study Completion

April 1, 2019

Last Updated

March 2, 2022

Record last verified: 2018-03

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)