Sarcopenia Cut-points and Functionality in Older Adults

NCT03832608 | Completed

• 1 other identifier: H1542733812827
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cross-sectional study conducted in older adults living in Valencia Province in order to establish the cut-off points of the multicriteria diagnostic of sarcopenia through functionality and frailty variables.

Conditions

Sarcopenia; Diagnostic

Keywords

Older adult; Sarcopenia; Frailty; Functionality; Muscle strength; Muscle mass; Walk speed

Outcome Measures

Primary Outcomes (5)

• First criteria of sarcopenia diagnostic: hand grip strength

  Muscle strength measured by the isometric hand grip strength (reference: Age and Aging. 2010;39:412-23).

  The cohort group will be assessed in one day visit.

• First criteria of sarcopenia diagnostic: knew extension strength

  Muscle strength measured by the isometric knew extension (reference: Phys Ther. 1996;76(3):248-59).

  The cohort group will be assessed in one day visit.

• First criteria of sarcopenia diagnostic: elbow flexion strength

  Muscle strength measured by the isometric elbow flexion (reference: Phys Ther. 1996;76(3):248-59).

  The cohort group will be assessed in one day visit.

• Second criteria of sarcopenia diagnostic: muscle mass

  Muscle mass estimated by Bioimpedance analysis (BIA) (reference: J Aging Phys Act. 2015;23(4):597-606).

  The cohort group will be assessed in one day visit.

• Third criteria of sarcopenia diagnostic: walk speed

  Walk speed measured by the Short Physical Performance Balance test (SPPB) (reference: J Gerontol A Biol Sci Med Sc 2000; 55(4):M221-31.

  The cohort group will be assessed in one day visit.

Secondary Outcomes (7)

• Functionality: Modified Baecke Questionnaire

  The cohort group will be assessed in one day visit.

• Functionality: Barthel Index

  The cohort group will be assessed in one day visit.

• Functionality: Lawton and Brody Questionnaire

  The cohort group will be assessed in one day visit.

• Frailty: Fried Scale

  The cohort group will be assessed in one day visit.

• Frailty:Frail Scale

  The cohort group will be assessed in one day visit.

Study Arms (1)

Older adults and Sarcopenia

Older adults with and without Sarcopenia living in Valencia Province.

Other: No intervention

Interventions

No intervention OTHER

There is not intervention to be administered, only collection of data through various tests and questionnaires.

Older adults and Sarcopenia

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adults (+65 years) living in Valence Province.

You may qualify if:

• People aged \> 65 years
• Residents in Valencia Province (Living-Community, Day-Centers and institutionalized)

You may not qualify if:

• Lobo Mini-exam cognoscitive \< 18 score
• Any disorder that prevents from performing the assessment tests.
• Recent hospitalization or who are in a acute process of any illness (less one month).

Sponsors & Collaborators

• University of Valencia: lead

Study Sites (1)

Armonea Group

Valencia, 46015, Spain

Location

Related Publications (9)

• Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.

  PMID: 20392703 BACKGROUND

• Masanes F, Culla A, Navarro-Gonzalez M, Navarro-Lopez M, Sacanella E, Torres B, Lopez-Soto A. Prevalence of sarcopenia in healthy community-dwelling elderly in an urban area of Barcelona (Spain). J Nutr Health Aging. 2012 Feb;16(2):184-7. doi: 10.1007/s12603-011-0108-3.

  PMID: 22323356 BACKGROUND

• Salva A, Serra-Rexach JA, Artaza I, Formiga F, Rojano I Luque X, Cuesta F, Lopez-Soto A, Masanes F, Ruiz D, Cruz-Jentoft AJ. [Prevalence of sarcopenia in Spanish nursing homes: Comparison of the results of the ELLI study with other populations]. Rev Esp Geriatr Gerontol. 2016 Sep-Oct;51(5):260-4. doi: 10.1016/j.regg.2016.02.004. Epub 2016 Apr 9. Spanish.

  PMID: 27068239 BACKGROUND

• Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, Chou MY, Chen LY, Hsu PS, Krairit O, Lee JS, Lee WJ, Lee Y, Liang CK, Limpawattana P, Lin CS, Peng LN, Satake S, Suzuki T, Won CW, Wu CH, Wu SN, Zhang T, Zeng P, Akishita M, Arai H. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014 Feb;15(2):95-101. doi: 10.1016/j.jamda.2013.11.025.

  PMID: 24461239 BACKGROUND

• Lee WJ, Liu LK, Peng LN, Lin MH, Chen LK; ILAS Research Group. Comparisons of sarcopenia defined by IWGS and EWGSOP criteria among older people: results from the I-Lan longitudinal aging study. J Am Med Dir Assoc. 2013 Jul;14(7):528.e1-7. doi: 10.1016/j.jamda.2013.03.019. Epub 2013 May 10.

  PMID: 23664768 BACKGROUND

• Ethgen O, Beaudart C, Buckinx F, Bruyere O, Reginster JY. The Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action. Calcif Tissue Int. 2017 Mar;100(3):229-234. doi: 10.1007/s00223-016-0220-9. Epub 2016 Dec 24.

  PMID: 28012107 BACKGROUND

• Cebria I Iranzo MA, Arnal-Gomez A, Tortosa-Chulia MA, Balasch-Bernat M, Forcano S, Sentandreu-Mano T, Tomas JM, Cezon-Serrano N. Functional and Clinical Characteristics for Predicting Sarcopenia in Institutionalised Older Adults: Identifying Tools for Clinical Screening. Int J Environ Res Public Health. 2020 Jun 22;17(12):4483. doi: 10.3390/ijerph17124483.

  PMID: 32580427 RESULT

• Arnal-Gomez A, Cebria I Iranzo MA, Tomas JM, Tortosa-Chulia MA, Balasch-Bernat M, Sentandreu-Mano T, Forcano S, Cezon-Serrano N. Using the Updated EWGSOP2 Definition in Diagnosing Sarcopenia in Spanish Older Adults: Clinical Approach. J Clin Med. 2021 Mar 2;10(5):1018. doi: 10.3390/jcm10051018.

  PMID: 33801427 RESULT

• Balasch-Bernat M, Sentandreu-Mano T, Tomas JM, Cebria I Iranzo MA, Tortosa-Chulia MA, Arnal-Gomez A, Cezon-Serrano N. Deepening the understanding of the structural validity of the Tilburg Frailty Indicator. Aging Clin Exp Res. 2023 Jun;35(6):1263-1271. doi: 10.1007/s40520-023-02407-w. Epub 2023 Apr 21.

  PMID: 37085651 DERIVED

MeSH Terms

Conditions

Sarcopenia; Disease; Frailty

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pathologic Processes

Study Officials

• Maria A Cebrià i Iranzo, PT, PhD

  University of Valencia

  PRINCIPAL INVESTIGATOR

• Mercè Balasch i Bernat, PT, PhD

  University of Valencia

  STUDY CHAIR

• Anna Arnal Gómez, PT, PhD

  University of Valencia

  STUDY CHAIR

• Trinidad Sentandreu Mañó, PT, PhD

  University of Valencia

  STUDY CHAIR

• Maria A Tortosa Chuliá, PhD

  University of Valencia

  STUDY CHAIR

• Natalia Cezón Serrano, PT

  University of Valencia

  STUDY CHAIR

• Jose M Tomás, PhD

  University of Valencia

  STUDY CHAIR

• Silvia Forcano Sanjuán, MD

  Hospital Universitari i Politècnic La Fe (Valencia)

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: January 31, 2019
• First Posted: February 6, 2019
• Study Start: January 8, 2019
• Primary Completion: March 31, 2021
• Study Completion: March 31, 2021
• Last Updated: May 3, 2021

Record last verified: 2021-04

Locations

ES (1)