Study Stopped
End of the inclusion period and difficulty in recruiting the youngest patients
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis
DIANE
Multicenter, Diagnostic and Prospective Study to Differentiate Child Septic and Inflammatory Arthritis by Comparative Analysis
2 other identifiers
observational
100
1 country
5
Brief Summary
The purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular phenotyping, will be analysed. The results for each data will be compared in function of the disease to search discriminant markers. On behalf with this result specific pathways could be identified .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2019
Typical duration for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 23, 2019
CompletedFirst Posted
Study publicly available on registry
February 1, 2019
CompletedStudy Start
First participant enrolled
February 4, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 6, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 29, 2022
CompletedApril 24, 2026
June 1, 2025
2.3 years
January 23, 2019
April 21, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Qualitative analysis of new biological markers (proteic) that discriminate inflammatory and infectious arthritis
Identify blood sampling proteic markers of Arthritis childhood
1 day
Qualitative analysis of new biological markers (cytokine) that discriminate inflammatory and infectious arthritis
Identify blood sampling markers (cytokine : interleukin 2, interleukin 4, interleukin 6, interleukin 7, tumor necrosis factor alpha (TNF)) of Arthritis childhood
1 day
Qualitative analysis of new cellular markers that discriminate inflammatory and infectious arthritis
Identify blood sampling cellular markers (lymphocytes and monocytes) of Arthritis childhood
1 day
Secondary Outcomes (1)
Qualitative analysis of inflammatory process markers
1 day
Study Arms (3)
septic arthritis (group A)
Patients with acute juvenile arthritis with suspicion of bacterial infection,confirmed on a bacteriological plan, either by culture of the articular liquid or by blood culture, or by molecular biology in the articular liquid;
inflammatory arthritis (group B)
Patients with idiopathic juvenile arthritis
control (group C)
Healthy children who are matched by the age and at the sex in the groups A and B, to analyze elements studied in the blood.
Eligibility Criteria
Subjects of more than 6 months and under age 15 years, presenting acute arthritis, and control subjects
You may qualify if:
- Group A and group B:
- Subject of more than 6 months and under age 15 years,
- Presenting acute arthritis taken care in the University Hospitals of Montpellier, Nimes, Toulouse or Lyon, and requiring an articular puncture,
- Child benefiting from a social security system,
- Collection of the consent of the legal parents/representatives,
- Group C:
- Subject of more than 6 months and under age 15 include,
- Taken care in the University Hospital of Montpellier, and requiring a venous draining,
- Child benefiting from a social security system,
- Collection of the consent of the legal parents/representatives
You may not qualify if:
- Group A and group B:
- Contraindication in an articular draining: platelet 50 000/mm3, pathologic hemostasis
- Treatment by biological therapy, corticoids or other immunosuppressant treatment in the month preceding the articular draining,
- Group C:
- Patient achieves of an inflammatory chronic pathology
- Patient having presented an infectious episode in the previous 8 days
- Patients under immunosuppressor or anti-infective
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
CHU Montpellier - Pediatric emergencies
Montpellier, Hérault, 34295, France
Hospices Civils de Lyon - pediatric rheumatology
Lyon, 69002, France
Hôpital Saint Joseph
Marseille, 13285, France
CHU Nîmes - Pediatrics
Nîmes, 30029, France
CHU Toulouse - Pediatric infectious diseases
Toulouse, 31300, France
Related Publications (1)
Cren M, Nziza N, Carbasse A, Mahe P, Dufourcq-Lopez E, Delpont M, Chevassus H, Khalil M, Mura T, Duroux-Richard I, Apparailly F, Jeziorski E, Louis-Plence P. Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis. Front Immunol. 2020 Jul 31;11:1716. doi: 10.3389/fimmu.2020.01716. eCollection 2020.
PMID: 32849606RESULT
Biospecimen
Synovial liquid and blood samples (with : proteomic, MiRNA searching, multiplex cytokine analysis and cellular phenotyping) will be analysed.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Eric JEZIORSKI, MD PhD
University Hospital, Montpellier
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 23, 2019
First Posted
February 1, 2019
Study Start
February 4, 2019
Primary Completion
June 6, 2021
Study Completion
July 29, 2022
Last Updated
April 24, 2026
Record last verified: 2025-06