Respiratory Functions, Trunk Control and Mobility Evaluation in Multiple Sclerosis

NCT03826095 | Completed

• 1 other identifier: Assesment in MS
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Respiratory functions and body control are affected in patients with multiple sclerosis (MS). Because of this effect, the dependency of individuals increases in daily living activities and their quality of life decreases. We think that respiratory functions, respiratory muscle strength and trunk control affect vital mobility as well as vital importance for individuals with MS. As a result of the investigations, it is concluded that the literature is insufficient in this area. The aim of this study is to investigate the effects of pulmonary function, respiratory muscle strength and trunk control on functional mobility in individuals with MS and compare with healthy individuals.

Conditions

Physical Therapy

Keywords

Multiple Sclerosis; Respiratory function; Respiratory muscle strength; Trunk control; Functional mobility

Outcome Measures

Primary Outcomes (2)

• 2 Minutes Walking Test

  Two Minute Walk Test (2MWT) will be performed to evaluate functional mobility.

  baseline

• Timed Up and Go Test

  Timed Up and Go Test will be performed to evaluate functional mobility.

  baseline

Secondary Outcomes (10)

• Respiratory Functions Test

  baseline

• Respiratory Muscle Strength

  baseline

• Trunk Impairment Scale

  baseline

• Side Bridge Test (core muscles endurance)

  baseline

• Modified Biering-Sorensen test (core muscles endurance)

  baseline

Study Arms (2)

Multiple Sclerosis

Patients with a clinically definitive diagnosis of MS, 0-5.5 Extended Disability Status Scale range.

Healthy individuals

Voluntary healthy individuals with similar age and gender

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

MS patients who are ambulatory Healthy volunteer individuals of similar age and sex to patients

You may qualify if:

• years old
• Having a definite MS diagnosis
• Up to 5.5 points on the Scored Disability Status Scale (EDSS)
• In the last 3 months have not experienced an attack
• Mini mental test score of 24 and above
• Acceptance to participate in the study.

You may not qualify if:

• Having orthopedic problems
• The presence of other neurological problems

Sponsors & Collaborators

• Hacettepe University: lead
• KARMUTLU: collaborator
• MATUNCER: collaborator
• EÇKÜTÜKÇÜ: collaborator

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

Related Publications (18)

• Tzelepis GE, McCool FD. Respiratory dysfunction in multiple sclerosis. Respir Med. 2015 Jun;109(6):671-9. doi: 10.1016/j.rmed.2015.01.018. Epub 2015 Feb 12.

  PMID: 25724874 BACKGROUND

• Smeltzer SC, Skurnick JH, Troiano R, Cook SD, Duran W, Lavietes MH. Respiratory function in multiple sclerosis. Utility of clinical assessment of respiratory muscle function. Chest. 1992 Feb;101(2):479-84. doi: 10.1378/chest.101.2.479.

  PMID: 1735276 BACKGROUND

• Smeltzer SC, Utell MJ, Rudick RA, Herndon RM. Pulmonary function and dysfunction in multiple sclerosis. Arch Neurol. 1988 Nov;45(11):1245-9. doi: 10.1001/archneur.1988.00520350083020.

  PMID: 3190505 BACKGROUND

• Mutluay FK, Gurses HN, Saip S. Effects of multiple sclerosis on respiratory functions. Clin Rehabil. 2005 Jun;19(4):426-32. doi: 10.1191/0269215505cr782oa.

  PMID: 15929512 BACKGROUND

• Smeltzer SC, Lavietes MH. Reliability of maximal respiratory pressures in multiple sclerosis. Chest. 1999 Jun;115(6):1546-52. doi: 10.1378/chest.115.6.1546.

  PMID: 10378547 BACKGROUND

• Sadovnick AD, Eisen K, Ebers GC, Paty DW. Cause of death in patients attending multiple sclerosis clinics. Neurology. 1991 Aug;41(8):1193-6. doi: 10.1212/wnl.41.8.1193.

  PMID: 1866003 BACKGROUND

• Mutluay FK, Demir R, Ozyilmaz S, Caglar AT, Altintas A, Gurses HN. Breathing-enhanced upper extremity exercises for patients with multiple sclerosis. Clin Rehabil. 2007 Jul;21(7):595-602. doi: 10.1177/0269215507075492.

  PMID: 17702701 BACKGROUND

• Lanzetta D, Cattaneo D, Pellegatta D, Cardini R. Trunk control in unstable sitting posture during functional activities in healthy subjects and patients with multiple sclerosis. Arch Phys Med Rehabil. 2004 Feb;85(2):279-83. doi: 10.1016/j.apmr.2003.05.004.

  PMID: 14966714 BACKGROUND

• Fry DK, Huang M, Rodda BJ. Core muscle strength and endurance measures in ambulatory persons with multiple sclerosis: validity and reliability. Int J Rehabil Res. 2015 Sep;38(3):206-12. doi: 10.1097/MRR.0000000000000109.

  PMID: 25647356 BACKGROUND

• Sebastiao E, Sandroff BM, Learmonth YC, Motl RW. Validity of the Timed Up and Go Test as a Measure of Functional Mobility in Persons With Multiple Sclerosis. Arch Phys Med Rehabil. 2016 Jul;97(7):1072-7. doi: 10.1016/j.apmr.2015.12.031. Epub 2016 Mar 2.

  PMID: 26944709 BACKGROUND

• American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624. doi: 10.1164/rccm.166.4.518. No abstract available.

  PMID: 12186831 BACKGROUND

• Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis. 1969 May;99(5):696-702. doi: 10.1164/arrd.1969.99.5.696. No abstract available.

  PMID: 5772056 BACKGROUND

• Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36. doi: 10.1164/ajrccm.152.3.7663792. No abstract available.

  PMID: 7663792 BACKGROUND

• Verheyden G, Nuyens G, Nieuwboer A, Van Asch P, Ketelaer P, De Weerdt W. Reliability and validity of trunk assessment for people with multiple sclerosis. Phys Ther. 2006 Jan;86(1):66-76. doi: 10.1093/ptj/86.1.66.

  PMID: 16386063 BACKGROUND

• Gijbels D, Eijnde BO, Feys P. Comparison of the 2- and 6-minute walk test in multiple sclerosis. Mult Scler. 2011 Oct;17(10):1269-72. doi: 10.1177/1352458511408475. Epub 2011 Jun 3.

  PMID: 21642370 BACKGROUND

• Bliss LS, Teeple P. Core stability: the centerpiece of any training program. Curr Sports Med Rep. 2005 Jun;4(3):179-83. doi: 10.1007/s11932-005-0064-y.

  PMID: 15907272 BACKGROUND

• Moreau CE, Green BN, Johnson CD, Moreau SR. Isometric back extension endurance tests: a review of the literature. J Manipulative Physiol Ther. 2001 Feb;24(2):110-22. doi: 10.1067/mmt.2001.112563.

  PMID: 11208223 BACKGROUND

• Ozen MS, Calik-Kutukcu E, Salci Y, Karanfil E, Tuncer A, Armutlu K. Is there a relationship between respiratory function and trunk control and functional mobility in patients with relapsing-remitting multiple sclerosis? Neurol Res. 2023 Jul;45(7):619-626. doi: 10.1080/01616412.2023.2176628. Epub 2023 Feb 13.

  PMID: 36780377 DERIVED

Related Links

• Mills JD, Taunton JE, Mills WA. The effect of a 10-week training regimen on lumbo-pelvic stability and athletic performance in female athletes: a randomized-controlled trial. Physical Therapy in Sport. 2005;6(2):60-6.

MeSH Terms

Conditions

Multiple Sclerosis; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• MELIKE S CENGİZ

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 23, 2019
• First Posted: February 1, 2019
• Study Start: February 4, 2019
• Primary Completion: July 26, 2019
• Study Completion: August 2, 2019
• Last Updated: August 6, 2019

Record last verified: 2019-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)